Cellular immune phenotypes and worsening scores of frailty-associated parameters over an 18-month period in the very old

David Goldeck, Wim Adriaensen, Lilly Oettinger, Bert Vaes, Gijs van Pottelbergh, Jean-Marie Degryse, Klaus Hamprecht, Catharina Matheï, Graham Pawelec

Research output: Contribution to journalA1: Web of Science-articlepeer-review

15 Downloads (Pure)


Frailty has been related to inflammaging and certain immune parameters. In previous analyses of participants older than 80 years of age in the longitudinal BELFRAIL cohort study, the main focus was on T-cell phenotypes and the association with cytomegalovirus (CMV) serostatus and survival, finding that a CD4:CD8 ratio greater than 5 was associated with frailty, impaired activities of daily living (ADLs), and mortality (but only in women). Here, we phenotyped peripheral blood immune cells via multicolor flow cytometry and correlated these with the dynamics of changes in ADL, geriatric depression score, Mini-Mental State Examination, and Short Physical Performance Battery from baseline values over 18 months follow-up. We found that higher frequencies of B cells and late-differentiated CD8+ T cells at 18 months from baseline were associated with ADL impairment that had worsened over the preceding 18 months. There were no significant associations with monocyte, dendritic cell, or natural killer (NK) cell phenotypes. No associations with the Geriatric Depression Scale, the Mini-Mental State Examination, or the Short Physical Performance Battery were found. Thus, while these results do not establish causality, they suggest that certain adaptive immune, but not innate immune, parameters are associated with a worsened ADL in the very old.

Original languageEnglish
JournalThe Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Issue number8
Pages (from-to)1356-1361
Number of pages6
Publication statusPublished - 2021


  • Activities of Daily Living
  • Adaptive Immunity/physiology
  • Aged, 80 and over
  • Aging/physiology
  • CD8-Positive T-Lymphocytes/immunology
  • Correlation of Data
  • Female
  • Frailty/blood
  • Humans
  • Immunologic Tests/methods
  • Immunosenescence/physiology
  • Killer Cells, Natural/immunology
  • Male
  • Mental Status and Dementia Tests/statistics & numerical data
  • Physical Functional Performance


Dive into the research topics of 'Cellular immune phenotypes and worsening scores of frailty-associated parameters over an 18-month period in the very old'. Together they form a unique fingerprint.

Cite this