Challenges and advances towards the rational design of mRNA vaccines

C. Pollard, S. De Koker, X. Saelens, G. Vanham, J. Grooten

Research output: Contribution to journalA1: Web of Science-articlepeer-review


In recent years, mRNA vaccines have emerged as a safe and potent approach for the induction of cellular immune responses. Whereas initial studies were limited to the ex vivo loading of dendritic cells (DCs) with antigen-encoding mRNA, recent progress has led to the development of improved mRNA vaccines that enable direct in vivo targeting of DCs. Although preclinical studies demonstrated their potency in inducing antitumor immunity, several bottlenecks hinder the broader application of mRNA vaccines. In this review, we discuss the challenges associated with mRNA-based vaccination strategies, the technological advances that have been made to overcome these limitations, and the hurdles that remain to be tackled for the development of an optimal mRNA vaccine.
Original languageEnglish
JournalTrends in Molecular Medicine
Issue number12
Pages (from-to)705-713
Number of pages9
Publication statusPublished - 2013

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