Chromosome rearrrangement in Leishmania mexicana M379

J Liu; N Gajendran; D Muthui; S Muyldermans; JC Dujardin; S De Doncker; D Jacquet; D Le Ray; F Mathieu-Daudé; R Hamers

doi:10.1016/0166-6851(91)90198-F

Chromosome rearrrangement in Leishmania mexicana M379

J Liu
, N Gajendran
, D Muthui
, S Muyldermans
, JC Dujardin
, S De Doncker
, D Jacquet
, D Le Ray
, F Mathieu-Daudé
, R Hamers

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

Abstract

Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb. The circular DNA molecule and its related region on the linear chromosome were cloned and their restriction maps compared. This investigation reveals information about chromosome rearrangement in L. mexicana M379. Further examination will enable us to understand the nature of chromosome rearrangement such as circularization or linearization.

Original language	English
Journal	Molecular and Biochemical Parasitology
Volume	46
Issue number	1
Pages (from-to)	53-60
Number of pages	8
ISSN	0166-6851
DOIs	https://doi.org/10.1016/0166-6851(91)90198-F
Publication status	Published - 1991

Keywords

B780-tropical-medicine
Protozoology
Leishmania mexicana
Chromosomes
Laboratory
Genetics

Access to Document

10.1016/0166-6851(91)90198-F

Cite this

@article{e3068a7f78f44015979b1a605c2ba419,

title = "Chromosome rearrrangement in Leishmania mexicana M379",

abstract = "Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb. The circular DNA molecule and its related region on the linear chromosome were cloned and their restriction maps compared. This investigation reveals information about chromosome rearrangement in L. mexicana M379. Further examination will enable us to understand the nature of chromosome rearrangement such as circularization or linearization.",

keywords = "B780-tropical-medicine, Protozoology, Leishmania mexicana, Chromosomes, Laboratory, Genetics",

author = "J Liu and N Gajendran and D Muthui and S Muyldermans and JC Dujardin and \{De Doncker\}, S and D Jacquet and \{Le Ray\}, D and F Mathieu-Daud{\'e} and R Hamers",

note = "FTX: Available in ITM print journal collection",

year = "1991",

doi = "10.1016/0166-6851(91)90198-F",

language = "English",

volume = "46",

pages = "53--60",

journal = "Molecular and Biochemical Parasitology",

issn = "0166-6851",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Chromosome rearrrangement in Leishmania mexicana M379

AU - Liu, J

AU - Gajendran, N

AU - Muthui, D

AU - Muyldermans, S

AU - Dujardin, JC

AU - De Doncker, S

AU - Jacquet, D

AU - Le Ray, D

AU - Mathieu-Daudé, F

AU - Hamers, R

N1 - FTX: Available in ITM print journal collection

PY - 1991

Y1 - 1991

N2 - Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb. The circular DNA molecule and its related region on the linear chromosome were cloned and their restriction maps compared. This investigation reveals information about chromosome rearrangement in L. mexicana M379. Further examination will enable us to understand the nature of chromosome rearrangement such as circularization or linearization.

AB - Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb. The circular DNA molecule and its related region on the linear chromosome were cloned and their restriction maps compared. This investigation reveals information about chromosome rearrangement in L. mexicana M379. Further examination will enable us to understand the nature of chromosome rearrangement such as circularization or linearization.

KW - B780-tropical-medicine

KW - Protozoology

KW - Leishmania mexicana

KW - Chromosomes

KW - Laboratory

KW - Genetics

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:A1991FJ36100006

U2 - 10.1016/0166-6851(91)90198-F

DO - 10.1016/0166-6851(91)90198-F

M3 - A1: Peer-reviewed journal articles

SN - 0166-6851

VL - 46

SP - 53

EP - 60

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

IS - 1

ER -

Chromosome rearrrangement in Leishmania mexicana M379

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this