TY - JOUR
T1 - Clinical features and treatment outcomes of visceral leishmaniasis patients admitted to three centers in Oromia, Ethiopia
AU - Tekalign, Samson
AU - Adera, Cherinet
AU - Den Boer, Margriet
AU - Miecha, Hirpha
AU - Zewde, Ashenafi
AU - Mulugeta, Dagnachew
AU - Bishawu, Tesfahun
AU - Birru, Weyuma
AU - Lema, Awoke
AU - Sahlu, Tilahun
AU - Alves, Fabiana
AU - Manzi, Marcel
AU - Takarinda, Kudakwashe
AU - Van Griensven, Johan
N1 - FTX; DOAJ; (CC BY 4.0); Copyright (c) 2020 Samson Tekalign, Cherinet Adera, Margriet den Boer, Hirpha Miecha, Ashenafi Zewde, Dagnachew Mulugeta, Tesfahun Bishawu, Weyuma Birru, Awoke Lema, Tilahun Sahlu, Fabiana Alves, Marcel Manzi, Kudakwashe Takarinda, Johan van Griensven.
PY - 2020
Y1 - 2020
N2 - INTRODUCTION: In three health care facilities in the Oromia region, the aim of this study is to report on 1) the number of VL cases registered over time (2013-2018) and 2) the clinical profile, type of treatment used and response to treatment.METHODOLOGY: A retrospective cohort study was conducted among all VL cases admitted with a diagnosis of VL.RESULTS: A total of 434 VL cases were registered at the three health facilities, but patient files were available for only 188. Most (51.6%) were children and only three presented with VL relapse. 78 (41.5%) of the 188 patients presented within one month of symptom onset. Concurrent severe acute malnutrition (27.1%), tuberculosis (6.4%) and malaria (6.4%) were common. There were only two cases with HIV coinfection. Fourty-three percent were treated with antimonials, 34% with antimonials combined with paromomycin and 23% with AmBisome. Amongst the 188 patients with patient files there were no deaths and one treatment failure. Six months outcome data were however missing for all. Aggregated data from the 434 VL cases reported three deaths, two treatment failures and one relapse.CONCLUSIONS: Children were most commonly affected, suggesting long-term endemicity. While short-term outcomes are encouraging, long-term follow-up data are required.
AB - INTRODUCTION: In three health care facilities in the Oromia region, the aim of this study is to report on 1) the number of VL cases registered over time (2013-2018) and 2) the clinical profile, type of treatment used and response to treatment.METHODOLOGY: A retrospective cohort study was conducted among all VL cases admitted with a diagnosis of VL.RESULTS: A total of 434 VL cases were registered at the three health facilities, but patient files were available for only 188. Most (51.6%) were children and only three presented with VL relapse. 78 (41.5%) of the 188 patients presented within one month of symptom onset. Concurrent severe acute malnutrition (27.1%), tuberculosis (6.4%) and malaria (6.4%) were common. There were only two cases with HIV coinfection. Fourty-three percent were treated with antimonials, 34% with antimonials combined with paromomycin and 23% with AmBisome. Amongst the 188 patients with patient files there were no deaths and one treatment failure. Six months outcome data were however missing for all. Aggregated data from the 434 VL cases reported three deaths, two treatment failures and one relapse.CONCLUSIONS: Children were most commonly affected, suggesting long-term endemicity. While short-term outcomes are encouraging, long-term follow-up data are required.
U2 - 10.3855/jidc.11731
DO - 10.3855/jidc.11731
M3 - A1: Web of Science-article
C2 - 32614795
SN - 1972-2680
VL - 14
SP - 42S-47S
JO - Journal of Infection in Developing Countries
JF - Journal of Infection in Developing Countries
IS - 6.1
ER -