Clinical manifestations and case management of ebola haemorrhagic fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008

P. Roddy, N. Howard, M.D. Van Kerkhove, J. Lutwama, J. Wamala, Z. Yoti, R. Colebunders, P.P. Palma, E. Sterk, B. Jeffs, M. Van Herp, M. Borchert

    Research output: Contribution to journalA1: Web of Science-article

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    Abstract

    A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical manifestations and case management for 26 hospitalised laboratory-confirmed EHF patients. Clinical findings are congruous with previously reported EHF infections. The most frequently experienced symptoms were non-bloody diarrhoea (81%), severe headache (81%), and asthenia (77%). Seven patients reported or were observed with haemorrhagic symptoms, six of whom died. Ebola care remains difficult due to the resource-poor setting of outbreaks and the infection-control procedures required. However, quality data collection is essential to evaluate case definitions and therapeutic interventions, and needs improvement in future epidemics. Organizations usually involved in EHF case management have a particular responsibility in this respect.
    Original languageEnglish
    JournalPLoS ONE
    Volume7
    Issue number12
    Pages (from-to)e52986
    ISSN1932-6203
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Viral diseases
    • Ebola virus disease
    • Hemorrhagic fevers
    • Outbreaks
    • Clinical manifestations
    • Case management
    • Strains
    • Bundibugyo ebolavirus
    • Symptoms
    • Diarrhea
    • Headache
    • Asthenia
    • Recommendations
    • Data collection
    • Uganda
    • Africa-East

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