Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands

Marc-Alain Widdowson, Wim J M Jaspers, Wim H M van der Poel, Froukje Verschoor, Ana Maria de Roda Husman, H L J Winter, Hans L Zaaijer, Marion Koopmans

Research output: Contribution to journalArticle

Abstract

Increasing evidence suggests that hepatitis E virus (HEV) infection may occur in developed countries and that swine may act as a reservoir. We report a cluster of 2 confirmed cases and 1 presumptive case of hepatitis associated with HEV. The typed strain from 1 case was related to HEV strains found in North America and Europe, and it was also related to a cluster of swine HEV strains found in The Netherlands. Our findings indicate that locally acquired HEV infections in industrialized countries may be overlooked. Routine testing for HEV infection in patients with acute hepatitis in The Netherlands should be considered before a diagnosis of autoimmune hepatitis is reached and steroid therapy is initiated.

Original languageEnglish
JournalClinical Infectious Diseases
Volume36
Issue number1
Pages (from-to)29-33
Number of pages5
ISSN1058-4838
DOIs
Publication statusPublished - 1-Jan-2003

Keywords

  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Animals
  • Carrier State
  • Disease Reservoirs/veterinary
  • Female
  • Hepatitis E/epidemiology
  • Hepatitis E virus/isolation & purification
  • Humans
  • Netherlands/epidemiology
  • Swine Diseases/virology

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