Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands

Marc-Alain Widdowson; Wim J M Jaspers; Wim H M van der Poel; Froukje Verschoor; Ana Maria de Roda Husman; H L J Winter; Hans L Zaaijer; Marion Koopmans

doi:10.1086/345439

Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands

Marc-Alain Widdowson, Wim J M Jaspers, Wim H M van der Poel, Froukje Verschoor, Ana Maria de Roda Husman, H L J Winter, Hans L Zaaijer, Marion Koopmans

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Increasing evidence suggests that hepatitis E virus (HEV) infection may occur in developed countries and that swine may act as a reservoir. We report a cluster of 2 confirmed cases and 1 presumptive case of hepatitis associated with HEV. The typed strain from 1 case was related to HEV strains found in North America and Europe, and it was also related to a cluster of swine HEV strains found in The Netherlands. Our findings indicate that locally acquired HEV infections in industrialized countries may be overlooked. Routine testing for HEV infection in patients with acute hepatitis in The Netherlands should be considered before a diagnosis of autoimmune hepatitis is reached and steroid therapy is initiated.

Original language	English
Journal	Clinical Infectious Diseases
Volume	36
Issue number	1
Pages (from-to)	29-33
Number of pages	5
ISSN	1058-4838
DOIs	https://doi.org/10.1086/345439
Publication status	Published - 2003

Keywords

Acute Disease
Aged
Aged, 80 and over
Animals
Carrier State
Disease Reservoirs/veterinary
Female
Hepatitis E/epidemiology
Hepatitis E virus/isolation & purification
Humans
Netherlands/epidemiology
Swine Diseases/virology

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10.1086/345439

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title = "Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands",

abstract = "Increasing evidence suggests that hepatitis E virus (HEV) infection may occur in developed countries and that swine may act as a reservoir. We report a cluster of 2 confirmed cases and 1 presumptive case of hepatitis associated with HEV. The typed strain from 1 case was related to HEV strains found in North America and Europe, and it was also related to a cluster of swine HEV strains found in The Netherlands. Our findings indicate that locally acquired HEV infections in industrialized countries may be overlooked. Routine testing for HEV infection in patients with acute hepatitis in The Netherlands should be considered before a diagnosis of autoimmune hepatitis is reached and steroid therapy is initiated.",

keywords = "Acute Disease, Aged, Aged, 80 and over, Animals, Carrier State, Disease Reservoirs/veterinary, Female, Hepatitis E/epidemiology, Hepatitis E virus/isolation & purification, Humans, Netherlands/epidemiology, Swine Diseases/virology",

author = "Marc-Alain Widdowson and Jaspers, {Wim J M} and {van der Poel}, {Wim H M} and Froukje Verschoor and {de Roda Husman}, {Ana Maria} and Winter, {H L J} and Zaaijer, {Hans L} and Marion Koopmans",

year = "2003",

doi = "10.1086/345439",

language = "English",

volume = "36",

pages = "29--33",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands

AU - Widdowson, Marc-Alain

AU - Jaspers, Wim J M

AU - van der Poel, Wim H M

AU - Verschoor, Froukje

AU - de Roda Husman, Ana Maria

AU - Winter, H L J

AU - Zaaijer, Hans L

AU - Koopmans, Marion

PY - 2003

Y1 - 2003

N2 - Increasing evidence suggests that hepatitis E virus (HEV) infection may occur in developed countries and that swine may act as a reservoir. We report a cluster of 2 confirmed cases and 1 presumptive case of hepatitis associated with HEV. The typed strain from 1 case was related to HEV strains found in North America and Europe, and it was also related to a cluster of swine HEV strains found in The Netherlands. Our findings indicate that locally acquired HEV infections in industrialized countries may be overlooked. Routine testing for HEV infection in patients with acute hepatitis in The Netherlands should be considered before a diagnosis of autoimmune hepatitis is reached and steroid therapy is initiated.

AB - Increasing evidence suggests that hepatitis E virus (HEV) infection may occur in developed countries and that swine may act as a reservoir. We report a cluster of 2 confirmed cases and 1 presumptive case of hepatitis associated with HEV. The typed strain from 1 case was related to HEV strains found in North America and Europe, and it was also related to a cluster of swine HEV strains found in The Netherlands. Our findings indicate that locally acquired HEV infections in industrialized countries may be overlooked. Routine testing for HEV infection in patients with acute hepatitis in The Netherlands should be considered before a diagnosis of autoimmune hepatitis is reached and steroid therapy is initiated.

KW - Acute Disease

KW - Aged

KW - Aged, 80 and over

KW - Animals

KW - Carrier State

KW - Disease Reservoirs/veterinary

KW - Female

KW - Hepatitis E/epidemiology

KW - Hepatitis E virus/isolation & purification

KW - Humans

KW - Netherlands/epidemiology

KW - Swine Diseases/virology

U2 - 10.1086/345439

DO - 10.1086/345439

M3 - A1: Web of Science-article

C2 - 12491198

SN - 1058-4838

VL - 36

SP - 29

EP - 33

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 1

ER -

Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in the Netherlands

Abstract

Keywords

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