Concentrations of ciprofloxacin in the world's rivers are associated with the prevalence of fluoroquinolone resistance in Escherichia coli: a global ecological analysis

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Abstract

BACKGROUND: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in Escherichia coli.

METHODS: Spearman's regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in E. coli and the median ciprofloxacin concentration in the country's rivers.

RESULTS: The prevalence of fluoroquinolone resistance in E. coli was positively correlated with the concentration of ciprofloxacin in rivers (ρ = 0.36; p = 0.011; n = 48).

DISCUSSION: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in E. coli and other bacterial species.

Original languageEnglish
Article number417
JournalAntibiotics-Basel
Volume11
Issue number3
Number of pages6
ISSN2079-6382
DOIs
Publication statusPublished - 2022

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