Concentrations of ciprofloxacin in the world's rivers are associated with the prevalence of fluoroquinolone resistance in Escherichia coli: a global ecological analysis

Chris Kenyon

doi:10.3390/antibiotics11030417

Concentrations of ciprofloxacin in the world's rivers are associated with the prevalence of fluoroquinolone resistance in Escherichia coli: a global ecological analysis

Chris Kenyon

Sexually Transmitted Infections

Research output: Contribution to journal › A1: Web of Science-article › peer-review

20 Downloads (Pure)

Abstract

BACKGROUND: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in Escherichia coli.

METHODS: Spearman's regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in E. coli and the median ciprofloxacin concentration in the country's rivers.

RESULTS: The prevalence of fluoroquinolone resistance in E. coli was positively correlated with the concentration of ciprofloxacin in rivers (ρ = 0.36; p = 0.011; n = 48).

DISCUSSION: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in E. coli and other bacterial species.

Original language	English
Article number	417
Journal	Antibiotics-Basel
Volume	11
Issue number	3
Number of pages	6
ISSN	2079-6382
DOIs	https://doi.org/10.3390/antibiotics11030417
Publication status	Published - 2022

Access to Document

10.3390/antibiotics11030417Licence: CC BY

2022anti0417Final published version, 381 KBLicence: CC BY

Cite this

@article{93c0e28664a74721a9987c6bd9c7b6ad,

title = "Concentrations of ciprofloxacin in the world's rivers are associated with the prevalence of fluoroquinolone resistance in Escherichia coli: a global ecological analysis",

abstract = "BACKGROUND: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in Escherichia coli.METHODS: Spearman's regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in E. coli and the median ciprofloxacin concentration in the country's rivers.RESULTS: The prevalence of fluoroquinolone resistance in E. coli was positively correlated with the concentration of ciprofloxacin in rivers (ρ = 0.36; p = 0.011; n = 48).DISCUSSION: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in E. coli and other bacterial species.",

author = "Chris Kenyon",

note = "FTX; (CC BY 4.0)",

year = "2022",

doi = "10.3390/antibiotics11030417",

language = "English",

volume = "11",

journal = "Antibiotics-Basel",

issn = "2079-6382",

publisher = "MDPI AG",

number = "3",

}

TY - JOUR

T1 - Concentrations of ciprofloxacin in the world's rivers are associated with the prevalence of fluoroquinolone resistance in Escherichia coli: a global ecological analysis

AU - Kenyon, Chris

N1 - FTX; (CC BY 4.0)

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in Escherichia coli.METHODS: Spearman's regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in E. coli and the median ciprofloxacin concentration in the country's rivers.RESULTS: The prevalence of fluoroquinolone resistance in E. coli was positively correlated with the concentration of ciprofloxacin in rivers (ρ = 0.36; p = 0.011; n = 48).DISCUSSION: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in E. coli and other bacterial species.

AB - BACKGROUND: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in Escherichia coli.METHODS: Spearman's regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in E. coli and the median ciprofloxacin concentration in the country's rivers.RESULTS: The prevalence of fluoroquinolone resistance in E. coli was positively correlated with the concentration of ciprofloxacin in rivers (ρ = 0.36; p = 0.011; n = 48).DISCUSSION: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in E. coli and other bacterial species.

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=itm_wosliteitg&SrcAuth=WosAPI&KeyUT=WOS:000775443200001&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.3390/antibiotics11030417

DO - 10.3390/antibiotics11030417

M3 - A1: Web of Science-article

C2 - 35326880

SN - 2079-6382

VL - 11

JO - Antibiotics-Basel

JF - Antibiotics-Basel

IS - 3

M1 - 417

ER -

Concentrations of ciprofloxacin in the world's rivers are associated with the prevalence of fluoroquinolone resistance in Escherichia coli: a global ecological analysis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this