Control of viral replication after cessation of HAART

E Van Gulck; L Heyndrickx; L Bracke; S Coppens; E Florence; A Buvé; P Lewi; G Vanham

doi:10.1186/1742-6405-8-6

Control of viral replication after cessation of HAART

E Van Gulck, L Heyndrickx, L Bracke, S Coppens, E Florence, A Buvé, P Lewi, G Vanham

Research output: Contribution to journal › A4: Article in journal not included in A1, A2 or A3 › peer-review

Abstract

We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual 'secondary controller' status. But their viruses are clearly less fit compared to viruses from rebounders.

Original language	English
Journal	AIDS Research and Therapy
Volume	8
Pages (from-to)	6
Number of pages	5
ISSN	1742-6405
DOIs	https://doi.org/10.1186/1742-6405-8-6
Publication status	Published - 2011

Keywords

B780-tropical-medicine
Viral diseases
HIV
AIDS
HAART
Antiretrovirals
Treatment outcome
Viral load
Replication
Case reports
CD4 lymphocyte count
Viral fitness
Belgium
Europe-West

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10.1186/1742-6405-8-6

Cite this

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title = "Control of viral replication after cessation of HAART",

abstract = "We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual 'secondary controller' status. But their viruses are clearly less fit compared to viruses from rebounders.",

keywords = "B780-tropical-medicine, Viral diseases, HIV, AIDS, HAART, Antiretrovirals, Treatment outcome, Viral load, Replication, Case reports, CD4 lymphocyte count, Viral fitness, Belgium, Europe-West",

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T1 - Control of viral replication after cessation of HAART

AU - Van Gulck, E

AU - Heyndrickx, L

AU - Bracke, L

AU - Coppens, S

AU - Florence, E

AU - Buvé, A

AU - Lewi, P

AU - Vanham, G

N1 - ITG-M1B; ITG-M2A; ITG-M3B; ITG-M4B; ITG-C5A; ITG-M6A; ITG-MLA; MULTI; MICRO; U-VIROL; U-HIVSTD; CLINIC; U-HIVCLI; DOI; URL; PDF; E-only; Abstract; DSPACE

PY - 2011

Y1 - 2011

N2 - We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual 'secondary controller' status. But their viruses are clearly less fit compared to viruses from rebounders.

AB - We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual 'secondary controller' status. But their viruses are clearly less fit compared to viruses from rebounders.

KW - B780-tropical-medicine

KW - Viral diseases

KW - HIV

KW - AIDS

KW - HAART

KW - Antiretrovirals

KW - Treatment outcome

KW - Viral load

KW - Replication

KW - Case reports

KW - CD4 lymphocyte count

KW - Viral fitness

KW - Belgium

KW - Europe-West

U2 - 10.1186/1742-6405-8-6

DO - 10.1186/1742-6405-8-6

M3 - A4: Article in journal not included in A1, A2 or A3

C2 - 21314914

SN - 1742-6405

VL - 8

SP - 6

JO - AIDS Research and Therapy

JF - AIDS Research and Therapy

ER -

Control of viral replication after cessation of HAART

Abstract

Keywords

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