Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: an ecological study

Sheeba S Manoharan-Basil; Natalia Gonzalez; Chris Kenyon

doi:10.1016/j.jiph.2022.01.012

Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: an ecological study

Sheeba S Manoharan-Basil, Natalia Gonzalez, Chris Kenyon

Sexually Transmitted Infections

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Abstract

BACKGROUND: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones.

METHODS: We used mixed-effects linear regression to assess if country-level prevalence of reduced susceptibility to cefotaxime and ciprofloxacin was associated with the population-level consumption of cephalosporins and quinolones in 13 European countries.

RESULTS: Positive correlations were found between the prevalence of reduced susceptibility to ciprofloxacin and the consumption of quinolones (coef. 0.16, 95% CI 0.05-0.27; P = 0.003). The same positive association was found for cefotaxime/cephalosporins (coef. 0.1, 95% CI 0.04-0.15; P = 0.001).

CONCLUSIONS: Meningococcal reduced susceptibility to cefotaxime and ciprofloxacin is linked to homologous class antimicrobial consumption. This finding provides additional motivation for strengthening antimicrobial stewardship programs.

Original language	English
Journal	Journal of Infection and Public Health
Volume	15
Issue number	3
Pages (from-to)	293-296
Number of pages	4
ISSN	1876-0341
DOIs	https://doi.org/10.1016/j.jiph.2022.01.012
Publication status	Published - 2022

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10.1016/j.jiph.2022.01.012Licence: CC BY-NC-ND

2022jiph0293Final published version, 419 KBLicence: CC BY-NC-ND

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title = "Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: an ecological study",

abstract = "BACKGROUND: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones.METHODS: We used mixed-effects linear regression to assess if country-level prevalence of reduced susceptibility to cefotaxime and ciprofloxacin was associated with the population-level consumption of cephalosporins and quinolones in 13 European countries.RESULTS: Positive correlations were found between the prevalence of reduced susceptibility to ciprofloxacin and the consumption of quinolones (coef. 0.16, 95% CI 0.05-0.27; P = 0.003). The same positive association was found for cefotaxime/cephalosporins (coef. 0.1, 95% CI 0.04-0.15; P = 0.001).CONCLUSIONS: Meningococcal reduced susceptibility to cefotaxime and ciprofloxacin is linked to homologous class antimicrobial consumption. This finding provides additional motivation for strengthening antimicrobial stewardship programs.",

author = "Manoharan-Basil, {Sheeba S} and Natalia Gonzalez and Chris Kenyon",

year = "2022",

doi = "10.1016/j.jiph.2022.01.012",

language = "English",

volume = "15",

pages = "293--296",

journal = "Journal of Infection and Public Health",

issn = "1876-0341",

publisher = "Elsevier",

number = "3",

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TY - JOUR

T1 - Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: an ecological study

AU - Manoharan-Basil, Sheeba S

AU - Gonzalez, Natalia

AU - Kenyon, Chris

PY - 2022

Y1 - 2022

N2 - BACKGROUND: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones.METHODS: We used mixed-effects linear regression to assess if country-level prevalence of reduced susceptibility to cefotaxime and ciprofloxacin was associated with the population-level consumption of cephalosporins and quinolones in 13 European countries.RESULTS: Positive correlations were found between the prevalence of reduced susceptibility to ciprofloxacin and the consumption of quinolones (coef. 0.16, 95% CI 0.05-0.27; P = 0.003). The same positive association was found for cefotaxime/cephalosporins (coef. 0.1, 95% CI 0.04-0.15; P = 0.001).CONCLUSIONS: Meningococcal reduced susceptibility to cefotaxime and ciprofloxacin is linked to homologous class antimicrobial consumption. This finding provides additional motivation for strengthening antimicrobial stewardship programs.

AB - BACKGROUND: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones.METHODS: We used mixed-effects linear regression to assess if country-level prevalence of reduced susceptibility to cefotaxime and ciprofloxacin was associated with the population-level consumption of cephalosporins and quinolones in 13 European countries.RESULTS: Positive correlations were found between the prevalence of reduced susceptibility to ciprofloxacin and the consumption of quinolones (coef. 0.16, 95% CI 0.05-0.27; P = 0.003). The same positive association was found for cefotaxime/cephalosporins (coef. 0.1, 95% CI 0.04-0.15; P = 0.001).CONCLUSIONS: Meningococcal reduced susceptibility to cefotaxime and ciprofloxacin is linked to homologous class antimicrobial consumption. This finding provides additional motivation for strengthening antimicrobial stewardship programs.

U2 - 10.1016/j.jiph.2022.01.012

DO - 10.1016/j.jiph.2022.01.012

M3 - A1: Web of Science-article

C2 - 35121411

SN - 1876-0341

VL - 15

SP - 293

EP - 296

JO - Journal of Infection and Public Health

JF - Journal of Infection and Public Health

IS - 3

ER -

Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: an ecological study

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