Country-level association between antimicrobial consumption and resistance in Neisseria meningitidis: an ecological study

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Abstract

BACKGROUND: It is unclear what is responsible for the large variations in the prevalence of meningococcal resistance to cephalosporins and quinolones.

METHODS: We used mixed-effects linear regression to assess if country-level prevalence of reduced susceptibility to cefotaxime and ciprofloxacin was associated with the population-level consumption of cephalosporins and quinolones in 13 European countries.

RESULTS: Positive correlations were found between the prevalence of reduced susceptibility to ciprofloxacin and the consumption of quinolones (coef. 0.16, 95% CI 0.05-0.27; P = 0.003). The same positive association was found for cefotaxime/cephalosporins (coef. 0.1, 95% CI 0.04-0.15; P = 0.001).

CONCLUSIONS: Meningococcal reduced susceptibility to cefotaxime and ciprofloxacin is linked to homologous class antimicrobial consumption. This finding provides additional motivation for strengthening antimicrobial stewardship programs.

Original languageEnglish
JournalJournal of Infection and Public Health
Volume15
Issue number3
Pages (from-to)293-296
Number of pages4
ISSN1876-0341
DOIs
Publication statusPublished - 2022

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