Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients

Dutch ZonMw Influenza A(H1N1) 2009 Consortium

doi:10.1111/j.1750-2659.2012.00347.x

Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients

Dutch ZonMw Influenza A(H1N1) 2009 Consortium

Department of Public Health

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7·5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.

Original language	English
Journal	Influenza and Other Respiratory Viruses
Volume	6
Issue number	3
Pages (from-to)	e16-e20
ISSN	1750-2640
DOIs	https://doi.org/10.1111/j.1750-2659.2012.00347.x
Publication status	Published - 2012

Keywords

Adolescent
Adult
Aged
Child
Child, Preschool
Diarrhea/etiology
Disease Outbreaks
Female
Humans
Influenza A Virus, H1N1 Subtype/genetics
Influenza, Human/complications
Male
Middle Aged
Netherlands/epidemiology
Pandemics
Viral Load
Young Adult

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10.1111/j.1750-2659.2012.00347.xLicence: CC BY

2012iorv0e16Final published version, 146 KBLicence: CC BY

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title = "Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients",

abstract = "The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7·5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.",

keywords = "Adolescent, Adult, Aged, Child, Child, Preschool, Diarrhea/etiology, Disease Outbreaks, Female, Humans, Influenza A Virus, H1N1 Subtype/genetics, Influenza, Human/complications, Male, Middle Aged, Netherlands/epidemiology, Pandemics, Viral Load, Young Adult",

author = "{Dutch ZonMw Influenza A(H1N1) 2009 Consortium} and Friesema, {Ingrid H M} and Adam Meijer and {van Gageldonk-Lafeber}, {Arianne B} and {van der Lubben}, Mariken and {van Beek}, Janko and Donker, {G{\'e} A} and Prins, {Jan M} and {de Jong}, {Menno D} and Simone Boskamp and Isken, {Leslie D} and Koopmans, {Marion P G} and {van der Sande}, {Marianne A B}",

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year = "2012",

doi = "10.1111/j.1750-2659.2012.00347.x",

language = "English",

volume = "6",

pages = "e16--e20",

journal = "Influenza and Other Respiratory Viruses",

issn = "1750-2640",

publisher = "John Wiley & Sons",

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TY - JOUR

T1 - Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients

AU - Dutch ZonMw Influenza A(H1N1) 2009 Consortium

AU - Friesema, Ingrid H M

AU - Meijer, Adam

AU - van Gageldonk-Lafeber, Arianne B

AU - van der Lubben, Mariken

AU - van Beek, Janko

AU - Donker, Gé A

AU - Prins, Jan M

AU - de Jong, Menno D

AU - Boskamp, Simone

AU - Isken, Leslie D

AU - Koopmans, Marion P G

AU - van der Sande, Marianne A B

PY - 2012

Y1 - 2012

N2 - The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7·5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.

AB - The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7·5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.

KW - Adolescent

KW - Adult

KW - Aged

KW - Child

KW - Child, Preschool

KW - Diarrhea/etiology

KW - Disease Outbreaks

KW - Female

KW - Humans

KW - Influenza A Virus, H1N1 Subtype/genetics

KW - Influenza, Human/complications

KW - Male

KW - Middle Aged

KW - Netherlands/epidemiology

KW - Pandemics

KW - Viral Load

KW - Young Adult

U2 - 10.1111/j.1750-2659.2012.00347.x

DO - 10.1111/j.1750-2659.2012.00347.x

M3 - A1: Web of Science-article

C2 - 22372759

SN - 1750-2640

VL - 6

SP - e16-e20

JO - Influenza and Other Respiratory Viruses

JF - Influenza and Other Respiratory Viruses

IS - 3

ER -

Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients

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Keywords

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