Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients

Dutch ZonMw Influenza A(H1N1) 2009 consortium

Research output: Contribution to journalA1: Web of Science-article

Abstract

The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7·5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.

Original languageEnglish
JournalInfluenza and Other Respiratory Viruses
Volume6
Issue number3
Pages (from-to)e16-e20
ISSN1750-2640
DOIs
Publication statusPublished - 2012

Keywords

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Diarrhea/etiology
  • Disease Outbreaks
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype/genetics
  • Influenza, Human/complications
  • Male
  • Middle Aged
  • Netherlands/epidemiology
  • Pandemics
  • Viral Load
  • Young Adult

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