Current status of vaccination against African trypanosomiasis

S Magez; G Caljon; T Tran; B Stijlemans; M Radwanska

doi:10.1017/S0031182010000223

Current status of vaccination against African trypanosomiasis

S Magez, G Caljon, T Tran, B Stijlemans, M Radwanska

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

SUMMARYAnti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology

Original language	English
Journal	Parasitology
Volume	137
Issue number	14
Pages (from-to)	2017-2027
Number of pages	11
ISSN	0031-1820
DOIs	https://doi.org/10.1017/S0031182010000223
Publication status	Published - 2010

Keywords

B780-tropical-medicine
Protozoal diseases
Trypanosomiasis-African
Sleeping sickness
Trypanosoma brucei
Trypanosoma congolense
Trypanosoma evansi
Trypanosoma equiperdum
Trypanosoma vivax
Tsetse flies
Glossina morsitans
Vaccination
B-cells
Surface antigen
Flagellates
VSG
Transmission prevention
Saliva
Pathogenicity
Immune suppression
Review of the literature
Vectors

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10.1017/S0031182010000223

http://lib.itg.be/pdf/itg/2010/2010para2017.pdf

Cite this

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title = "Current status of vaccination against African trypanosomiasis",

abstract = "SUMMARYAnti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology",

keywords = "B780-tropical-medicine, Protozoal diseases, Trypanosomiasis-African, Sleeping sickness, Trypanosoma brucei, Trypanosoma congolense, Trypanosoma evansi, Trypanosoma equiperdum, Trypanosoma vivax, Tsetse flies, Glossina morsitans, Vaccination, B-cells, Surface antigen, Flagellates, VSG, Transmission prevention, Saliva, Pathogenicity, Immune suppression, Review of the literature, Vectors",

author = "S Magez and G Caljon and T Tran and B Stijlemans and M Radwanska",

note = "ITG-P2B; PARAS; U-ENTOM; JIF; DOI; PDF; Abstract; DSPACE",

year = "2010",

doi = "10.1017/S0031182010000223",

language = "English",

volume = "137",

pages = "2017--2027",

journal = "Parasitology",

issn = "0031-1820",

publisher = "Cambridge University Press",

number = "14",

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TY - JOUR

T1 - Current status of vaccination against African trypanosomiasis

AU - Magez, S

AU - Caljon, G

AU - Tran, T

AU - Stijlemans, B

AU - Radwanska, M

N1 - ITG-P2B; PARAS; U-ENTOM; JIF; DOI; PDF; Abstract; DSPACE

PY - 2010

Y1 - 2010

N2 - SUMMARYAnti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology

AB - SUMMARYAnti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology

KW - B780-tropical-medicine

KW - Protozoal diseases

KW - Trypanosomiasis-African

KW - Sleeping sickness

KW - Trypanosoma brucei

KW - Trypanosoma congolense

KW - Trypanosoma evansi

KW - Trypanosoma equiperdum

KW - Trypanosoma vivax

KW - Tsetse flies

KW - Glossina morsitans

KW - Vaccination

KW - B-cells

KW - Surface antigen

KW - Flagellates

KW - VSG

KW - Transmission prevention

KW - Saliva

KW - Pathogenicity

KW - Immune suppression

KW - Review of the literature

KW - Vectors

U2 - 10.1017/S0031182010000223

DO - 10.1017/S0031182010000223

M3 - A1: Web of Science-article

C2 - 20441680

VL - 137

SP - 2017

EP - 2027

JO - Parasitology

JF - Parasitology

SN - 0031-1820

IS - 14

ER -

Current status of vaccination against African trypanosomiasis

Abstract

Keywords

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