Current status of vaccination against African trypanosomiasis

S Magez, G Caljon, T Tran, B Stijlemans, M Radwanska

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    SUMMARYAnti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology
    Original languageEnglish
    JournalParasitology
    Volume137
    Issue number14
    Pages (from-to)2017-2027
    Number of pages11
    ISSN0031-1820
    DOIs
    Publication statusPublished - 2010

    Keywords

    • B780-tropical-medicine
    • Protozoal diseases
    • Trypanosomiasis-African
    • Sleeping sickness
    • Trypanosoma brucei
    • Trypanosoma congolense
    • Trypanosoma evansi
    • Trypanosoma equiperdum
    • Trypanosoma vivax
    • Tsetse flies
    • Glossina morsitans
    • Vaccination
    • B-cells
    • Surface antigen
    • Flagellates
    • VSG
    • Transmission prevention
    • Saliva
    • Pathogenicity
    • Immune suppression
    • Review of the literature
    • Vectors

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