Detectable HIV-1 in semen in individuals with very low blood viral loads

Samuel Mundia Kariuki, Philippe Selhorst, Jennifer Norman, Karen Cohen, Kevin Rebe, Carolyn Williamson, Jeffrey R. Dorfman

Research output: Contribution to journalA1: Web of Science-article

Abstract

Background Several reports indicate that a portion (5-10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive of an HIV-1 reservoir in the male genital tract. However, the status of this reservoir in men living with HIV-1 who are not under treatment is underexplored and has implications for understanding the origins and evolution of the reservoir. Finding Forty-three HIV-1 positive, antiretroviral therapy naive study participants attending a men's health clinic were studied. Semen viral loads and blood viral loads were generally correlated, with semen viral loads generally detected in individuals with blood viral loads > 10,000 cp/ml. However, we found 1 individual with undetectable viral loads (

Original languageEnglish
Article number29
JournalVirology Journal
Volume17
Issue number1
Number of pages5
DOIs
Publication statusPublished - 2020

Keywords

  • HIV-1
  • Semen
  • Blood
  • Viral load
  • SEMINAL PLASMA
  • MEN
  • RNA
  • TRANSMISSION
  • CELLS
  • SEX
  • PROTEASE
  • THERAPY
  • DISEASE

Cite this