Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection

JL Penalvo; T Nurmi; K Haajanen; N Al-Maharik; N Botting; H Adlercreutz

doi:10.1016/j.ab.2004.05.046

Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection

JL Penalvo, T Nurmi, K Haajanen, N Al-Maharik, N Botting, H Adlercreutz

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

The presence of mammalian lignans, mainly enterolactone, in human plasma has been related to lower incidence of certain cancers and cardiovascular disease. The plant lignans secoisolariciresinol and matairesinol have been reported to be precursors of mammalian lignans, but recently other plant lignans relatively abundant in the diet have also been identified as precursors. To evaluate the importance and contribution of these new dietary precursors to the mammalian lignan formation in vivo, metabolic studies in human subjects must be carried out. For this purpose a method based on high-performance liquid chromatography using coulometric electrode array detection for the simultaneous determination of nine plant lignans and two mammalian lignans in human plasma was developed, validated, and shown to fulfill the reliability criteria. (C) 2004 Elsevier Inc. All rights reserved.

Original language	English
Journal	Analytical Biochemistry
Volume	332
Issue number	2
Pages (from-to)	384-393
Number of pages	10
ISSN	0003-2697
DOIs	https://doi.org/10.1016/j.ab.2004.05.046
Publication status	Published - 15-Sept-2004
Externally published	Yes

Keywords

plant lignans
enterodiol
enterolactone
coulometric detector
human plasma
BREAST-CANCER CELLS
MASS-SPECTROMETRIC METHOD
MAMMALIAN LIGNANS
ANTIOXIDANT ACTIVITY
GAS-CHROMATOGRAPHY
SERUM CONCENTRATIONS
ENTEROLACTONE
ISOFLAVONOIDS
PHYTOESTROGENS
METABOLISM

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10.1016/j.ab.2004.05.046

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@article{64dc7df4654249328e48302b6c76c646,

title = "Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection",

abstract = "The presence of mammalian lignans, mainly enterolactone, in human plasma has been related to lower incidence of certain cancers and cardiovascular disease. The plant lignans secoisolariciresinol and matairesinol have been reported to be precursors of mammalian lignans, but recently other plant lignans relatively abundant in the diet have also been identified as precursors. To evaluate the importance and contribution of these new dietary precursors to the mammalian lignan formation in vivo, metabolic studies in human subjects must be carried out. For this purpose a method based on high-performance liquid chromatography using coulometric electrode array detection for the simultaneous determination of nine plant lignans and two mammalian lignans in human plasma was developed, validated, and shown to fulfill the reliability criteria. (C) 2004 Elsevier Inc. All rights reserved.",

keywords = "plant lignans, enterodiol, enterolactone, coulometric detector, human plasma, BREAST-CANCER CELLS, MASS-SPECTROMETRIC METHOD, MAMMALIAN LIGNANS, ANTIOXIDANT ACTIVITY, GAS-CHROMATOGRAPHY, SERUM CONCENTRATIONS, ENTEROLACTONE, ISOFLAVONOIDS, PHYTOESTROGENS, METABOLISM",

author = "JL Penalvo and T Nurmi and K Haajanen and N Al-Maharik and N Botting and H Adlercreutz",

year = "2004",

month = sep,

day = "15",

doi = "10.1016/j.ab.2004.05.046",

language = "English",

volume = "332",

pages = "384--393",

journal = "Analytical Biochemistry",

issn = "0003-2697",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection

AU - Penalvo, JL

AU - Nurmi, T

AU - Haajanen, K

AU - Al-Maharik, N

AU - Botting, N

AU - Adlercreutz, H

PY - 2004/9/15

Y1 - 2004/9/15

N2 - The presence of mammalian lignans, mainly enterolactone, in human plasma has been related to lower incidence of certain cancers and cardiovascular disease. The plant lignans secoisolariciresinol and matairesinol have been reported to be precursors of mammalian lignans, but recently other plant lignans relatively abundant in the diet have also been identified as precursors. To evaluate the importance and contribution of these new dietary precursors to the mammalian lignan formation in vivo, metabolic studies in human subjects must be carried out. For this purpose a method based on high-performance liquid chromatography using coulometric electrode array detection for the simultaneous determination of nine plant lignans and two mammalian lignans in human plasma was developed, validated, and shown to fulfill the reliability criteria. (C) 2004 Elsevier Inc. All rights reserved.

AB - The presence of mammalian lignans, mainly enterolactone, in human plasma has been related to lower incidence of certain cancers and cardiovascular disease. The plant lignans secoisolariciresinol and matairesinol have been reported to be precursors of mammalian lignans, but recently other plant lignans relatively abundant in the diet have also been identified as precursors. To evaluate the importance and contribution of these new dietary precursors to the mammalian lignan formation in vivo, metabolic studies in human subjects must be carried out. For this purpose a method based on high-performance liquid chromatography using coulometric electrode array detection for the simultaneous determination of nine plant lignans and two mammalian lignans in human plasma was developed, validated, and shown to fulfill the reliability criteria. (C) 2004 Elsevier Inc. All rights reserved.

KW - plant lignans

KW - enterodiol

KW - enterolactone

KW - coulometric detector

KW - human plasma

KW - BREAST-CANCER CELLS

KW - MASS-SPECTROMETRIC METHOD

KW - MAMMALIAN LIGNANS

KW - ANTIOXIDANT ACTIVITY

KW - GAS-CHROMATOGRAPHY

KW - SERUM CONCENTRATIONS

KW - ENTEROLACTONE

KW - ISOFLAVONOIDS

KW - PHYTOESTROGENS

KW - METABOLISM

U2 - 10.1016/j.ab.2004.05.046

DO - 10.1016/j.ab.2004.05.046

M3 - A1: Web of Science-article

SN - 0003-2697

VL - 332

SP - 384

EP - 393

JO - Analytical Biochemistry

JF - Analytical Biochemistry

IS - 2

ER -

Determination of lignans in human plasma by liquid chromatography with coulometric electrode array detection

Abstract

Keywords

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