Diagnosis of Human Immunodeficiency Virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay

G Hess; F Avillez; MH Lourenço; F D'Agostino; G Cambie; P Piot; G Vercauteren; U Michl; W Melchior; H Bayer

doi:10.1128/JCM.32.2.403-406.1994

Diagnosis of Human Immunodeficiency Virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay

G Hess, F Avillez, MH Lourenço, F D'Agostino, G Cambie, P Piot, G Vercauteren, U Michl, W Melchior, H Bayer

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

A new anti-human immunodeficiency virus type 1 and 2 (anti-HIV 1 and 2) test is described. It uses recombinant p24 and peptides covering gp32, gp41, and gp120 to identify HIV-1 and HIV-2 infections. This test has been shown to be specific (99.5%) and sensitive (99.8%). In this respect, the assay was equal or superior to anti-HIV 1 and 2 tests run as references. The test was able to discriminate sera from patients with HIV infections from those from uninfected individuals with excellence; it also exerted high intra- and interassay precisions. The "modular" concept of the test allows the use of single components (gp32 or gp41) to separate between HIV-2 and HIV-1 infections, respectively.

Original language	English
Journal	Journal of Clinical Microbiology
Volume	32
Issue number	2
Pages (from-to)	403-406
Number of pages	4
ISSN	0095-1137
DOIs	https://doi.org/10.1128/JCM.32.2.403-406.1994
Publication status	Published - 1994

Keywords

B780-tropical-medicine
Virology
HIV-1
HIV-2
Laboratory diagnosis
Immunoenzyme techniques
Laboratory techniques and procedures

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10.1128/JCM.32.2.403-406.1994

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Hess, G., Avillez, F., Lourenço, MH., D'Agostino, F., Cambie, G., Piot, P., Vercauteren, G., Michl, U., Melchior, W., & Bayer, H. (1994). Diagnosis of Human Immunodeficiency Virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay. Journal of Clinical Microbiology, 32(2), 403-406. https://doi.org/10.1128/JCM.32.2.403-406.1994

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abstract = "A new anti-human immunodeficiency virus type 1 and 2 (anti-HIV 1 and 2) test is described. It uses recombinant p24 and peptides covering gp32, gp41, and gp120 to identify HIV-1 and HIV-2 infections. This test has been shown to be specific (99.5%) and sensitive (99.8%). In this respect, the assay was equal or superior to anti-HIV 1 and 2 tests run as references. The test was able to discriminate sera from patients with HIV infections from those from uninfected individuals with excellence; it also exerted high intra- and interassay precisions. The {"}modular{"} concept of the test allows the use of single components (gp32 or gp41) to separate between HIV-2 and HIV-1 infections, respectively.",

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author = "G Hess and F Avillez and MH Louren{\c c}o and F D'Agostino and G Cambie and P Piot and G Vercauteren and U Michl and W Melchior and H Bayer",

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Hess, G, Avillez, F, Lourenço, MH, D'Agostino, F, Cambie, G, Piot, P, Vercauteren, G, Michl, U, Melchior, W & Bayer, H 1994, 'Diagnosis of Human Immunodeficiency Virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay', Journal of Clinical Microbiology, vol. 32, no. 2, pp. 403-406. https://doi.org/10.1128/JCM.32.2.403-406.1994

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T1 - Diagnosis of Human Immunodeficiency Virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay

AU - Hess, G

AU - Avillez, F

AU - Lourenço, MH

AU - D'Agostino, F

AU - Cambie, G

AU - Piot, P

AU - Vercauteren, G

AU - Michl, U

AU - Melchior, W

AU - Bayer, H

N1 - FTX: Abonnement

PY - 1994

Y1 - 1994

N2 - A new anti-human immunodeficiency virus type 1 and 2 (anti-HIV 1 and 2) test is described. It uses recombinant p24 and peptides covering gp32, gp41, and gp120 to identify HIV-1 and HIV-2 infections. This test has been shown to be specific (99.5%) and sensitive (99.8%). In this respect, the assay was equal or superior to anti-HIV 1 and 2 tests run as references. The test was able to discriminate sera from patients with HIV infections from those from uninfected individuals with excellence; it also exerted high intra- and interassay precisions. The "modular" concept of the test allows the use of single components (gp32 or gp41) to separate between HIV-2 and HIV-1 infections, respectively.

AB - A new anti-human immunodeficiency virus type 1 and 2 (anti-HIV 1 and 2) test is described. It uses recombinant p24 and peptides covering gp32, gp41, and gp120 to identify HIV-1 and HIV-2 infections. This test has been shown to be specific (99.5%) and sensitive (99.8%). In this respect, the assay was equal or superior to anti-HIV 1 and 2 tests run as references. The test was able to discriminate sera from patients with HIV infections from those from uninfected individuals with excellence; it also exerted high intra- and interassay precisions. The "modular" concept of the test allows the use of single components (gp32 or gp41) to separate between HIV-2 and HIV-1 infections, respectively.

KW - B780-tropical-medicine

KW - Virology

KW - HIV-1

KW - HIV-2

KW - Laboratory diagnosis

KW - Immunoenzyme techniques

KW - Laboratory techniques and procedures

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U2 - 10.1128/JCM.32.2.403-406.1994

DO - 10.1128/JCM.32.2.403-406.1994

M3 - A1: Web of Science-article

SN - 0095-1137

VL - 32

SP - 403

EP - 406

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 2

ER -

Diagnosis of Human Immunodeficiency Virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay

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