Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): Pierrea multi-country, prospective, non-experimental case-control study

Katja Polman; Sören L Becker; Emilie Alirol; Nisha K Bhatta; Narayan R Bhattarai; Emmanuel Bottieau; Martin W Bratschi; Sakib Burza; Jean T Coulibaly; Mama N Doumbia; Ninon S Horié; Jan Jacobs; Basudha Khanal; Aly Landouré; Yodi Mahendradhata; Filip Meheus; Pascal Mertens; Fransiska Meyanti; Elsa H Murhandarwati; Eliézer K N'Goran; Rosanna W Peeling; Raffaella Ravinetto; Suman Rijal; Moussa Sacko; Rénion Saye; Pierre H H Schneeberger; Céline Schurmans; Kigbafori D Silué; Jarir A Thobari; Mamadou S Traoré; Lisette van Lieshout; Harry van Loen; Kristien Verdonck; Lutz von Müller; Cédric P Yansouni; Joel A Yao; Patrick K Yao; Peiling Yap; Marleen Boelaert; François Chappuis; Jürg Utzinger

doi:10.1186/s12879-015-1074-x

Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): Pierrea multi-country, prospective, non-experimental case-control study

Katja Polman, Sören L Becker, Emilie Alirol, Nisha K Bhatta, Narayan R Bhattarai, Emmanuel Bottieau, Martin W Bratschi, Sakib Burza, Jean T Coulibaly, Mama N Doumbia, Ninon S Horié, Jan Jacobs, Basudha Khanal, Aly Landouré, Yodi Mahendradhata, Filip Meheus, Pascal Mertens, Fransiska Meyanti, Elsa H Murhandarwati, Eliézer K N'GoranRosanna W Peeling, Raffaella Ravinetto, Suman Rijal, Moussa Sacko, Rénion Saye, Pierre H H Schneeberger, Céline Schurmans, Kigbafori D Silué, Jarir A Thobari, Mamadou S Traoré, Lisette van Lieshout, Harry van Loen, Kristien Verdonck, Lutz von Müller, Cédric P Yansouni, Joel A Yao, Patrick K Yao, Peiling Yap, Marleen Boelaert, François Chappuis, Jürg Utzinger

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (≥14 days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.

METHODS/DESIGN: This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea (≥14 days; in individuals aged ≥1 year) and persistent abdominal pain (≥14 days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Côte d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.

DISCUSSION: Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.

TRIAL REGISTRATION: ClinicalTrials.gov; identifier: NCT02105714 .

Original language	English
Journal	BMC Infectious Diseases
Volume	15
Issue number	1
Pages (from-to)	338
ISSN	1471-2334
DOIs	https://doi.org/10.1186/s12879-015-1074-x
Publication status	Published - 2015

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10.1186/s12879-015-1074-x

2015bidi0338Final published version, 1.68 MBLicence: CC BY
2015bidi0499Final published version, 276 KBLicence: CC BY

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Polman, K., Becker, S. L., Alirol, E., Bhatta, N. K., Bhattarai, N. R., Bottieau, E., Bratschi, M. W., Burza, S., Coulibaly, J. T., Doumbia, M. N., Horié, N. S., Jacobs, J., Khanal, B., Landouré, A., Mahendradhata, Y., Meheus, F., Mertens, P., Meyanti, F., Murhandarwati, E. H., ... Utzinger, J. (2015). Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): Pierrea multi-country, prospective, non-experimental case-control study. BMC Infectious Diseases, 15(1), 338. https://doi.org/10.1186/s12879-015-1074-x

@article{7992e6118c2f486988e6f89b98cf3124,

title = "Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): Pierrea multi-country, prospective, non-experimental case-control study",

abstract = "BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (≥14 days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.METHODS/DESIGN: This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea (≥14 days; in individuals aged ≥1 year) and persistent abdominal pain (≥14 days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from C{\^o}te d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.DISCUSSION: Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.TRIAL REGISTRATION: ClinicalTrials.gov; identifier: NCT02105714 .",

author = "Katja Polman and Becker, {S{\"o}ren L} and Emilie Alirol and Bhatta, {Nisha K} and Bhattarai, {Narayan R} and Emmanuel Bottieau and Bratschi, {Martin W} and Sakib Burza and Coulibaly, {Jean T} and Doumbia, {Mama N} and Hori{\'e}, {Ninon S} and Jan Jacobs and Basudha Khanal and Aly Landour{\'e} and Yodi Mahendradhata and Filip Meheus and Pascal Mertens and Fransiska Meyanti and Murhandarwati, {Elsa H} and N'Goran, {Eli{\'e}zer K} and Peeling, {Rosanna W} and Raffaella Ravinetto and Suman Rijal and Moussa Sacko and R{\'e}nion Saye and Schneeberger, {Pierre H H} and C{\'e}line Schurmans and Silu{\'e}, {Kigbafori D} and Thobari, {Jarir A} and Traor{\'e}, {Mamadou S} and {van Lieshout}, Lisette and {van Loen}, Harry and Kristien Verdonck and {von M{\"u}ller}, Lutz and Yansouni, {C{\'e}dric P} and Yao, {Joel A} and Yao, {Patrick K} and Peiling Yap and Marleen Boelaert and Fran{\c c}ois Chappuis and J{\"u}rg Utzinger",

note = "Polman K, Becker SL, Alirol E, Bhatta NK, Bhattarai NR, Bottieau E, Bratschi MW, Burza S, Coulibaly JT, Doumbia MN, Hori{\'e} NS, Jacobs J, Khanal B, Landour{\'e} A, Mahendradhata Y, Meheus F, Mertens P, Meyanti F, Murhandarwati EH, N'Goran EK, Peeling RW, Ravinetto R, Rijal S, Sacko M, Saye R, Schneeberger PH, Schurmans C, Silu{\'e} KD, Thobari JA, Traor{\'e} MS, van Lieshout L, van Loen H, Verdonck K, von M{\"u}ller L, Yansouni CP, Yao JA, Yao PK, Yap P, Boelaert M, Chappuis F, Utzinger J. Erratum to: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case-control study. BMC Infect Dis. 2015 Nov 4;15:499. doi: 10.1186/s12879-015-1160-0. PubMed PMID: 26537896; PubMed Central PMCID: PMC4634142. FTX",

year = "2015",

doi = "10.1186/s12879-015-1074-x",

language = "English",

volume = "15",

pages = "338",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central",

number = "1",

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Polman, K, Becker, SL, Alirol, E, Bhatta, NK, Bhattarai, NR, Bottieau, E, Bratschi, MW, Burza, S, Coulibaly, JT, Doumbia, MN, Horié, NS, Jacobs, J, Khanal, B, Landouré, A, Mahendradhata, Y, Meheus, F, Mertens, P, Meyanti, F, Murhandarwati, EH, N'Goran, EK, Peeling, RW, Ravinetto, R, Rijal, S, Sacko, M, Saye, R, Schneeberger, PHH, Schurmans, C, Silué, KD, Thobari, JA, Traoré, MS, van Lieshout, L, van Loen, H , Verdonck, K, von Müller, L, Yansouni, CP, Yao, JA, Yao, PK, Yap, P, Boelaert, M, Chappuis, F & Utzinger, J 2015, 'Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): Pierrea multi-country, prospective, non-experimental case-control study', BMC Infectious Diseases, vol. 15, no. 1, pp. 338. https://doi.org/10.1186/s12879-015-1074-x

Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): Pierrea multi-country, prospective, non-experimental case-control study. / Polman, Katja; Becker, Sören L; Alirol, Emilie et al.
In: BMC Infectious Diseases, Vol. 15, No. 1, 2015, p. 338.

Research output: Contribution to journal › A1: Web of Science-article › peer-review

TY - JOUR

T1 - Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days)

T2 - Pierrea multi-country, prospective, non-experimental case-control study

AU - Polman, Katja

AU - Becker, Sören L

AU - Alirol, Emilie

AU - Bhatta, Nisha K

AU - Bhattarai, Narayan R

AU - Bottieau, Emmanuel

AU - Bratschi, Martin W

AU - Burza, Sakib

AU - Coulibaly, Jean T

AU - Doumbia, Mama N

AU - Horié, Ninon S

AU - Jacobs, Jan

AU - Khanal, Basudha

AU - Landouré, Aly

AU - Mahendradhata, Yodi

AU - Meheus, Filip

AU - Mertens, Pascal

AU - Meyanti, Fransiska

AU - Murhandarwati, Elsa H

AU - N'Goran, Eliézer K

AU - Peeling, Rosanna W

AU - Ravinetto, Raffaella

AU - Rijal, Suman

AU - Sacko, Moussa

AU - Saye, Rénion

AU - Schneeberger, Pierre H H

AU - Schurmans, Céline

AU - Silué, Kigbafori D

AU - Thobari, Jarir A

AU - Traoré, Mamadou S

AU - van Lieshout, Lisette

AU - van Loen, Harry

AU - Verdonck, Kristien

AU - von Müller, Lutz

AU - Yansouni, Cédric P

AU - Yao, Joel A

AU - Yao, Patrick K

AU - Yap, Peiling

AU - Boelaert, Marleen

AU - Chappuis, François

AU - Utzinger, Jürg

N1 - Polman K, Becker SL, Alirol E, Bhatta NK, Bhattarai NR, Bottieau E, Bratschi MW, Burza S, Coulibaly JT, Doumbia MN, Horié NS, Jacobs J, Khanal B, Landouré A, Mahendradhata Y, Meheus F, Mertens P, Meyanti F, Murhandarwati EH, N'Goran EK, Peeling RW, Ravinetto R, Rijal S, Sacko M, Saye R, Schneeberger PH, Schurmans C, Silué KD, Thobari JA, Traoré MS, van Lieshout L, van Loen H, Verdonck K, von Müller L, Yansouni CP, Yao JA, Yao PK, Yap P, Boelaert M, Chappuis F, Utzinger J. Erratum to: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case-control study. BMC Infect Dis. 2015 Nov 4;15:499. doi: 10.1186/s12879-015-1160-0. PubMed PMID: 26537896; PubMed Central PMCID: PMC4634142. FTX

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (≥14 days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.METHODS/DESIGN: This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea (≥14 days; in individuals aged ≥1 year) and persistent abdominal pain (≥14 days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Côte d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.DISCUSSION: Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.TRIAL REGISTRATION: ClinicalTrials.gov; identifier: NCT02105714 .

AB - BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (≥14 days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.METHODS/DESIGN: This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea (≥14 days; in individuals aged ≥1 year) and persistent abdominal pain (≥14 days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Côte d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.DISCUSSION: Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.TRIAL REGISTRATION: ClinicalTrials.gov; identifier: NCT02105714 .

U2 - 10.1186/s12879-015-1074-x

DO - 10.1186/s12879-015-1074-x

M3 - A1: Web of Science-article

C2 - 26282537

SN - 1471-2334

VL - 15

SP - 338

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

IS - 1

ER -