Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis

Eliane Tihon, Hideo Imamura, Jean-Claude Dujardin, Jan Van Den Abbeele, Frederik Van den Broeck

Research output: Contribution to journalA1: Web of Science-article

Abstract

Hybrid populations and introgressive hybridization remain poorly documented in pathogenic microorganisms, as such that genetic exchange has been argued to play a minor role in their evolution. Recent work demonstrated the existence of hybrid microsatellite profiles in Trypanosoma congolense, a parasitic protozoan with detrimental effects on livestock productivity in sub-Saharan Africa. Here we present the first population genomic study of T. congolense, revealing a remarkable number of Single Nucleotide Polymorphisms (SNPs), small insertions/deletions (indels) and gene deletions among 56 parasite genomes from ten African countries. One group of parasites from Zambia was particularly diverse, displaying a substantial number of heterozygous SNP and indel sites compared to T. congolense parasites from the nine other sub-Saharan countries. Genome-wide 5kb phylogenetic analyses based on phased SNP data revealed that these parasites were the product of hybridization between phylogenetically distinct T. congolense lineages. Other parasites within the same region in Zambia presented a mosaic of haplotypic ancestry and genetic variability, indicating that hybrid parasites persisted and recombined beyond the initial hybridization event. Our observations challenge traditional views of trypanosome population biology and encourage future research on the role of hybridization in spreading genes for drug resistance, pathogenicity and virulence. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalMolecular Ecology
Volume26
Issue number23
Pages (from-to)6524-6538
ISSN0962-1083
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Journal Article

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