Disease perception is correlated with health-related quality of life in patients suffering from Myelodysplastic syndromes: results of the Belgian Be-QUALMS study

Bert Heyrman; Stef Meers; Ann De Becker; Kristien Wouters; Achiel Van Hoof; Ann Van De Velde; Carlos Graux; Dominiek Mazure; Dominik Selleslag; Helena Maes; Jan Lemmens; Marielle Beckers; Dimitri Breems; Sélim Sid; Zwi Berneman; Sébastien Anguille

doi:10.3390/cancers15133296

Disease perception is correlated with health-related quality of life in patients suffering from Myelodysplastic syndromes: results of the Belgian Be-QUALMS study

Bert Heyrman, Stef Meers, Ann De Becker, Kristien Wouters, Achiel Van Hoof, Ann Van De Velde, Carlos Graux, Dominiek Mazure, Dominik Selleslag, Helena Maes, Jan Lemmens, Marielle Beckers, Dimitri Breems, Sélim Sid, Zwi Berneman, Sébastien Anguille

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Abstract

Patients with myelodysplastic syndromes suffer from an impaired quality of life that is only partially explained by physical symptoms. In an observational study, we aimed to investigate the impact of current MDS treatments and the influence of disease perception on quality of life. Serial measurement of health-related quality of life was performed by 'the QUALMS', a validated MDS-specific patient reported outcome tool. Disease perception was evaluated by means of the Brief Illness Perception Questionnaire (B-IPQ). We prospectively collected data on 75 patients that started on a new treatment and could not demonstrate a significant change in QUALMS score or B-IPQ score during treatment. Six out of eight items evaluated in the B-IPQ correlated significantly with QUALMS score. In this small sample, no significant difference in QUALMS score was found between lower vs. higher risk MDS patients or other studied variables, e.g., targeted hemoglobin showed no correlation with QUALMS score. In daily practice attention must be paid to initial formation of disease perception as it correlates independently with health-related quality of life and does not change during treatment (clinicaltrials.gov identifier: NCT04053933).

Original language	English
Article number	3296
Journal	Cancers
Volume	15
Issue number	13
ISSN	2072-6694
DOIs	https://doi.org/10.3390/cancers15133296
Publication status	Published - 2023

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10.3390/cancers15133296Licence: CC BY

2023canc3296Final published version, 901 KBLicence: CC BY

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Heyrman, B., Meers, S., De Becker, A., Wouters, K., Van Hoof, A., Van De Velde, A., Graux, C., Mazure, D., Selleslag, D., Maes, H., Lemmens, J., Beckers, M., Breems, D., Sid, S., Berneman, Z., & Anguille, S. (2023). Disease perception is correlated with health-related quality of life in patients suffering from Myelodysplastic syndromes: results of the Belgian Be-QUALMS study. Cancers, 15(13), Article 3296. https://doi.org/10.3390/cancers15133296

@article{18cdea704d514196ba71ed255052942f,

title = "Disease perception is correlated with health-related quality of life in patients suffering from Myelodysplastic syndromes: results of the Belgian Be-QUALMS study",

abstract = "Patients with myelodysplastic syndromes suffer from an impaired quality of life that is only partially explained by physical symptoms. In an observational study, we aimed to investigate the impact of current MDS treatments and the influence of disease perception on quality of life. Serial measurement of health-related quality of life was performed by 'the QUALMS', a validated MDS-specific patient reported outcome tool. Disease perception was evaluated by means of the Brief Illness Perception Questionnaire (B-IPQ). We prospectively collected data on 75 patients that started on a new treatment and could not demonstrate a significant change in QUALMS score or B-IPQ score during treatment. Six out of eight items evaluated in the B-IPQ correlated significantly with QUALMS score. In this small sample, no significant difference in QUALMS score was found between lower vs. higher risk MDS patients or other studied variables, e.g., targeted hemoglobin showed no correlation with QUALMS score. In daily practice attention must be paid to initial formation of disease perception as it correlates independently with health-related quality of life and does not change during treatment (clinicaltrials.gov identifier: NCT04053933).",

author = "Bert Heyrman and Stef Meers and {De Becker}, Ann and Kristien Wouters and {Van Hoof}, Achiel and {Van De Velde}, Ann and Carlos Graux and Dominiek Mazure and Dominik Selleslag and Helena Maes and Jan Lemmens and Marielle Beckers and Dimitri Breems and S{\'e}lim Sid and Zwi Berneman and S{\'e}bastien Anguille",

note = "FTX; DOAJ; (CC BY 4.0)",

year = "2023",

doi = "10.3390/cancers15133296",

language = "English",

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Heyrman, B, Meers, S, De Becker, A, Wouters, K, Van Hoof, A, Van De Velde, A, Graux, C, Mazure, D, Selleslag, D, Maes, H, Lemmens, J, Beckers, M, Breems, D, Sid, S, Berneman, Z & Anguille, S 2023, 'Disease perception is correlated with health-related quality of life in patients suffering from Myelodysplastic syndromes: results of the Belgian Be-QUALMS study', Cancers, vol. 15, no. 13, 3296. https://doi.org/10.3390/cancers15133296

TY - JOUR

T1 - Disease perception is correlated with health-related quality of life in patients suffering from Myelodysplastic syndromes: results of the Belgian Be-QUALMS study

AU - Heyrman, Bert

AU - Meers, Stef

AU - De Becker, Ann

AU - Wouters, Kristien

AU - Van Hoof, Achiel

AU - Van De Velde, Ann

AU - Graux, Carlos

AU - Mazure, Dominiek

AU - Selleslag, Dominik

AU - Maes, Helena

AU - Lemmens, Jan

AU - Beckers, Marielle

AU - Breems, Dimitri

AU - Sid, Sélim

AU - Berneman, Zwi

AU - Anguille, Sébastien

N1 - FTX; DOAJ; (CC BY 4.0)

PY - 2023

Y1 - 2023

N2 - Patients with myelodysplastic syndromes suffer from an impaired quality of life that is only partially explained by physical symptoms. In an observational study, we aimed to investigate the impact of current MDS treatments and the influence of disease perception on quality of life. Serial measurement of health-related quality of life was performed by 'the QUALMS', a validated MDS-specific patient reported outcome tool. Disease perception was evaluated by means of the Brief Illness Perception Questionnaire (B-IPQ). We prospectively collected data on 75 patients that started on a new treatment and could not demonstrate a significant change in QUALMS score or B-IPQ score during treatment. Six out of eight items evaluated in the B-IPQ correlated significantly with QUALMS score. In this small sample, no significant difference in QUALMS score was found between lower vs. higher risk MDS patients or other studied variables, e.g., targeted hemoglobin showed no correlation with QUALMS score. In daily practice attention must be paid to initial formation of disease perception as it correlates independently with health-related quality of life and does not change during treatment (clinicaltrials.gov identifier: NCT04053933).

AB - Patients with myelodysplastic syndromes suffer from an impaired quality of life that is only partially explained by physical symptoms. In an observational study, we aimed to investigate the impact of current MDS treatments and the influence of disease perception on quality of life. Serial measurement of health-related quality of life was performed by 'the QUALMS', a validated MDS-specific patient reported outcome tool. Disease perception was evaluated by means of the Brief Illness Perception Questionnaire (B-IPQ). We prospectively collected data on 75 patients that started on a new treatment and could not demonstrate a significant change in QUALMS score or B-IPQ score during treatment. Six out of eight items evaluated in the B-IPQ correlated significantly with QUALMS score. In this small sample, no significant difference in QUALMS score was found between lower vs. higher risk MDS patients or other studied variables, e.g., targeted hemoglobin showed no correlation with QUALMS score. In daily practice attention must be paid to initial formation of disease perception as it correlates independently with health-related quality of life and does not change during treatment (clinicaltrials.gov identifier: NCT04053933).

U2 - 10.3390/cancers15133296

DO - 10.3390/cancers15133296

M3 - A1: Web of Science-article

C2 - 37444406

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 13

M1 - 3296

ER -