Disseminated cutaneous leishmaniasis resembling post-kala-azar dermal leishmaniasis caused by Leishmania donovani in three patients co-infected with visceral leishmaniasis and human immunodeficiency virus/acquired immunodeficiency syndrome in Ethiopia

T Gelanew, Z Hurissa, E Diro, A Kassahun, K Kuhls, G Schönian, A Hailu

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    We report paired strains of Leishmania parasites, one from the viscera and the other from skin lesions that were isolated from three patients with visceral leishmaniasis and disseminated cutaneous leishmaniasis that were co-infected with human immunodeficiency virus. The causative parasites were characterized by polymerase chain reaction-restriction length polymorphism of the ribosomal DNA internal transcribed spacer 1 and by a panel of multilocus microsatellite markers. We demonstrated that the causative agent was Leishmania donovani in all cases, irrespective of the phenotype of the disease. The paired strains from viscera and skin lesions of the same patients showed genetic identity across the 14 microsatellite markers investigated. These findings demonstrate that the skin lesions in these human immunodeficiency virus-positive patients with visceral leishmaniasis were caused by dissemination of viscerotropic L. donovani parasites as a consequence of severe immunosuppression. However, in all three patients, rapid clearance of the skin lesions was observed after antimonial therapy.
    Original languageEnglish
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume84
    Issue number6
    Pages (from-to)906-912
    Number of pages7
    ISSN0002-9637
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Protozoal diseases
    • Cutaneous
    • Visceral
    • Leishmaniasis
    • Kala azar
    • Leishmania donovani
    • Vectors
    • Sandflies
    • Phlebotomus argentipes
    • Co-infections
    • Viral diseases
    • HIV
    • AIDS
    • Disease progression
    • Case reports
    • Skin lesions
    • Strains
    • Severe infection
    • Immunosuppression
    • Molecular
    • Characterization
    • Ethiopia
    • Africa-East

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