Distinct Salmonella enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

Nicholas A Feasey; James Hadfield; Karen H Keddy; Timothy J Dallman; Jan Jacobs; Xiangyu Deng; Paul Wigley; Lars Barquist Barquist; Gemma C Langridge; Theresa Feltwell; Simon R Harris; Alison E Mather; Maria Fookes; Martin Aslett; Chisomo Msefula; Samuel Kariuki; Calman A Maclennan; Robert S Onsare; François-Xavier Weill; Simon Le Hello; Anthony M Smith; Michael McClelland; Prerak Desai; Christopher M Parry; John Cheesbrough; Neil French; Josefina Campos; Jose A Chabalgoity; Laura Betancor; Katie L Hopkins; Satheesh Nair; Tom J Humphrey; Octavie Lunguya; Tristan A Cogan; Milagritos D Tapia; Samba O Sow; Sharon M Tennant; Kristin Bornstein; Myron M Levine; Lizeth Lacharme-Lora; Dean B Everett; Robert A Kingsley; Julian Parkhill; Robert S Heyderman; Gordon Dougan; Melita A Gordon; Nicholas R Thomson

doi:10.1038/ng.3644

Distinct Salmonella enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

Nicholas A Feasey, James Hadfield, Karen H Keddy, Timothy J Dallman, Jan Jacobs, Xiangyu Deng, Paul Wigley, Lars Barquist Barquist, Gemma C Langridge, Theresa Feltwell, Simon R Harris, Alison E Mather, Maria Fookes, Martin Aslett, Chisomo Msefula, Samuel Kariuki, Calman A Maclennan, Robert S Onsare, François-Xavier Weill, Simon Le HelloAnthony M Smith, Michael McClelland, Prerak Desai, Christopher M Parry, John Cheesbrough, Neil French, Josefina Campos, Jose A Chabalgoity, Laura Betancor, Katie L Hopkins, Satheesh Nair, Tom J Humphrey, Octavie Lunguya, Tristan A Cogan, Milagritos D Tapia, Samba O Sow, Sharon M Tennant, Kristin Bornstein, Myron M Levine, Lizeth Lacharme-Lora, Dean B Everett, Robert A Kingsley, Julian Parkhill, Robert S Heyderman, Gordon Dougan, Melita A Gordon, Nicholas R Thomson

Tropical Bacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

Original language	English
Journal	Nature Genetics
Volume	48
Issue number	10
Pages (from-to)	1211-1217
Number of pages	7
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.3644
Publication status	Published - 2016

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Feasey, N. A., Hadfield, J., Keddy, K. H., Dallman, T. J., Jacobs, J., Deng, X., Wigley, P., Barquist Barquist, L., Langridge, G. C., Feltwell, T., Harris, S. R., Mather, A. E., Fookes, M., Aslett, M., Msefula, C., Kariuki, S., Maclennan, C. A., Onsare, R. S., Weill, F.-X., ... Thomson, N. R. (2016). Distinct Salmonella enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nature Genetics, 48(10), 1211-1217. https://doi.org/10.1038/ng.3644

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title = "Distinct Salmonella enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings",

abstract = "An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.",

author = "Feasey, {Nicholas A} and James Hadfield and Keddy, {Karen H} and Dallman, {Timothy J} and Jan Jacobs and Xiangyu Deng and Paul Wigley and {Barquist Barquist}, Lars and Langridge, {Gemma C} and Theresa Feltwell and Harris, {Simon R} and Mather, {Alison E} and Maria Fookes and Martin Aslett and Chisomo Msefula and Samuel Kariuki and Maclennan, {Calman A} and Onsare, {Robert S} and Fran{\c c}ois-Xavier Weill and {Le Hello}, Simon and Smith, {Anthony M} and Michael McClelland and Prerak Desai and Parry, {Christopher M} and John Cheesbrough and Neil French and Josefina Campos and Chabalgoity, {Jose A} and Laura Betancor and Hopkins, {Katie L} and Satheesh Nair and Humphrey, {Tom J} and Octavie Lunguya and Cogan, {Tristan A} and Tapia, {Milagritos D} and Sow, {Samba O} and Tennant, {Sharon M} and Kristin Bornstein and Levine, {Myron M} and Lizeth Lacharme-Lora and Everett, {Dean B} and Kingsley, {Robert A} and Julian Parkhill and Heyderman, {Robert S} and Gordon Dougan and Gordon, {Melita A} and Thomson, {Nicholas R}",

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Feasey, NA, Hadfield, J, Keddy, KH, Dallman, TJ, Jacobs, J, Deng, X, Wigley, P, Barquist Barquist, L, Langridge, GC, Feltwell, T, Harris, SR, Mather, AE, Fookes, M, Aslett, M, Msefula, C, Kariuki, S, Maclennan, CA, Onsare, RS, Weill, F-X, Le Hello, S, Smith, AM, McClelland, M, Desai, P, Parry, CM, Cheesbrough, J, French, N, Campos, J, Chabalgoity, JA, Betancor, L, Hopkins, KL, Nair, S, Humphrey, TJ, Lunguya, O, Cogan, TA, Tapia, MD, Sow, SO, Tennant, SM, Bornstein, K, Levine, MM, Lacharme-Lora, L, Everett, DB, Kingsley, RA, Parkhill, J, Heyderman, RS, Dougan, G, Gordon, MA & Thomson, NR 2016, 'Distinct Salmonella enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings', Nature Genetics, vol. 48, no. 10, pp. 1211-1217. https://doi.org/10.1038/ng.3644

TY - JOUR

T1 - Distinct Salmonella enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

AU - Feasey, Nicholas A

AU - Hadfield, James

AU - Keddy, Karen H

AU - Dallman, Timothy J

AU - Jacobs, Jan

AU - Deng, Xiangyu

AU - Wigley, Paul

AU - Barquist Barquist, Lars

AU - Langridge, Gemma C

AU - Feltwell, Theresa

AU - Harris, Simon R

AU - Mather, Alison E

AU - Fookes, Maria

AU - Aslett, Martin

AU - Msefula, Chisomo

AU - Kariuki, Samuel

AU - Maclennan, Calman A

AU - Onsare, Robert S

AU - Weill, François-Xavier

AU - Le Hello, Simon

AU - Smith, Anthony M

AU - McClelland, Michael

AU - Desai, Prerak

AU - Parry, Christopher M

AU - Cheesbrough, John

AU - French, Neil

AU - Campos, Josefina

AU - Chabalgoity, Jose A

AU - Betancor, Laura

AU - Hopkins, Katie L

AU - Nair, Satheesh

AU - Humphrey, Tom J

AU - Lunguya, Octavie

AU - Cogan, Tristan A

AU - Tapia, Milagritos D

AU - Sow, Samba O

AU - Tennant, Sharon M

AU - Bornstein, Kristin

AU - Levine, Myron M

AU - Lacharme-Lora, Lizeth

AU - Everett, Dean B

AU - Kingsley, Robert A

AU - Parkhill, Julian

AU - Heyderman, Robert S

AU - Dougan, Gordon

AU - Gordon, Melita A

AU - Thomson, Nicholas R

N1 - NPP

PY - 2016

Y1 - 2016

N2 - An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

AB - An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

U2 - 10.1038/ng.3644

DO - 10.1038/ng.3644

M3 - A1: Web of Science-article

C2 - 27548315

SN - 1061-4036

VL - 48

SP - 1211

EP - 1217

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Distinct Salmonella enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

Abstract

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