Do cryptic reservoirs threaten gambiense-sleeping sickness elimination?

Philippe Büscher, Jean-Mathieu Bart, Marleen Boelaert, Bruno Bucheton, Giuliano Cecchi, Nakul Chitnis, David Courtin, Luisa M Figueiredo, José-Ramon Franco, Pascal Grébaut, Epco Hasker, Hamidou Ilboudo, Vincent Jamonneau, Mathurin Koffi, Veerle Lejon, Annette MacLeod, Justin Masumu, Enock Matovu, Raffaele Mattioli, Harry NoyesAlbert Picado, Kat S Rock, Brice Rotureau, Gustave Simo, Sophie Thévenon, Sandra Trindade, Philippe Truc, Nick Van Reet, Informal Expert Group on Gambiense HAT Reservoirs

    Research output: Contribution to journalA1: Web of Science-articlepeer-review


    Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination as a public health problem for 2020, and of interruption of transmission to humans for 2030. Latent human infections and possible animal reservoirs may challenge these goals. It remains largely unknown whether, and to what extend, they have an impact on gambiense-HAT transmission. We argue that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.

    Original languageEnglish
    JournalTrends In Parasitology
    Issue number3
    Pages (from-to)197-207
    Number of pages11
    Publication statusPublished - 2018


    • Journal Article
    • Review


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