Doxycycline Post Exposure Prophylaxis could induce cross-resistance to other classes of antimicrobials in Neisseria gonorrhoeae: an in-silico analysis

Thibaut Vanbaelen; Sheeba Santhini Manoharan-Basil; Chris Kenyon

doi:10.1097/OLQ.0000000000001810

Doxycycline Post Exposure Prophylaxis could induce cross-resistance to other classes of antimicrobials in Neisseria gonorrhoeae: an in-silico analysis

Thibaut Vanbaelen, Sheeba Santhini Manoharan-Basil, Chris Kenyon

Sexually Transmitted Infections

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

We found that tetracycline resistance-associated mutations and genes in Neisseria gonorrhoeae are linked to mutations causing resistance to other antimicrobials. Therefore, the use of doxycycline postexposure prophylaxis may select for resistance to other antimicrobials.

Original language	English
Journal	Sexually Transmitted Diseases
Volume	50
Issue number	8
Pages (from-to)	490-493
Number of pages	4
ISSN	0148-5717
DOIs	https://doi.org/10.1097/OLQ.0000000000001810
Publication status	Published - 2023

Keywords

Anti-Bacterial Agents/pharmacology
Anti-Infective Agents/pharmacology
Doxycycline/pharmacology
Drug Resistance, Bacterial/genetics
Gonorrhea/prevention & control
Humans
Microbial Sensitivity Tests
Neisseria gonorrhoeae/genetics
Tetracycline/pharmacology

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10.1097/OLQ.0000000000001810

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title = "Doxycycline Post Exposure Prophylaxis could induce cross-resistance to other classes of antimicrobials in Neisseria gonorrhoeae: an in-silico analysis",

abstract = "We found that tetracycline resistance-associated mutations and genes in Neisseria gonorrhoeae are linked to mutations causing resistance to other antimicrobials. Therefore, the use of doxycycline postexposure prophylaxis may select for resistance to other antimicrobials.",

keywords = "Anti-Bacterial Agents/pharmacology, Anti-Infective Agents/pharmacology, Doxycycline/pharmacology, Drug Resistance, Bacterial/genetics, Gonorrhea/prevention & control, Humans, Microbial Sensitivity Tests, Neisseria gonorrhoeae/genetics, Tetracycline/pharmacology",

author = "Thibaut Vanbaelen and Manoharan-Basil, {Sheeba Santhini} and Chris Kenyon",

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year = "2023",

doi = "10.1097/OLQ.0000000000001810",

language = "English",

volume = "50",

pages = "490--493",

journal = "Sexually Transmitted Diseases",

issn = "0148-5717",

publisher = "Lippincott Williams & Wilkins",

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}

Doxycycline Post Exposure Prophylaxis could induce cross-resistance to other classes of antimicrobials in Neisseria gonorrhoeae: an in-silico analysis. / Vanbaelen, Thibaut ; Manoharan-Basil, Sheeba Santhini ; Kenyon, Chris.
In: Sexually Transmitted Diseases, Vol. 50, No. 8, 2023, p. 490-493.

Research output: Contribution to journal › A1: Web of Science-article › peer-review

TY - JOUR

T1 - Doxycycline Post Exposure Prophylaxis could induce cross-resistance to other classes of antimicrobials in Neisseria gonorrhoeae: an in-silico analysis

AU - Vanbaelen, Thibaut

AU - Manoharan-Basil, Sheeba Santhini

AU - Kenyon, Chris

N1 - FTX abonnement

PY - 2023

Y1 - 2023

N2 - We found that tetracycline resistance-associated mutations and genes in Neisseria gonorrhoeae are linked to mutations causing resistance to other antimicrobials. Therefore, the use of doxycycline postexposure prophylaxis may select for resistance to other antimicrobials.

AB - We found that tetracycline resistance-associated mutations and genes in Neisseria gonorrhoeae are linked to mutations causing resistance to other antimicrobials. Therefore, the use of doxycycline postexposure prophylaxis may select for resistance to other antimicrobials.

KW - Anti-Bacterial Agents/pharmacology

KW - Anti-Infective Agents/pharmacology

KW - Doxycycline/pharmacology

KW - Drug Resistance, Bacterial/genetics

KW - Gonorrhea/prevention & control

KW - Humans

KW - Microbial Sensitivity Tests

KW - Neisseria gonorrhoeae/genetics

KW - Tetracycline/pharmacology

U2 - 10.1097/OLQ.0000000000001810

DO - 10.1097/OLQ.0000000000001810

M3 - A1: Web of Science-article

C2 - 36952471

SN - 0148-5717

VL - 50

SP - 490

EP - 493

JO - Sexually Transmitted Diseases

JF - Sexually Transmitted Diseases

IS - 8

ER -

Doxycycline Post Exposure Prophylaxis could induce cross-resistance to other classes of antimicrobials in Neisseria gonorrhoeae: an in-silico analysis

Abstract

Keywords

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