Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo

BC Bisimwa; E Bahizire; M Kiselinova; V Byela; JCS Ngabonziza; F Hakizayezu; D Runyambo; CJ Meehan; W Mulders; I Cuella-Martin; L Rigouts; F Birembano; S Callens; BC de Jong; M Kaswa

doi:10.1186/s12879-025-11348-w

Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo

BC Bisimwa, E Bahizire, M Kiselinova, V Byela, JCS Ngabonziza, F Hakizayezu, D Runyambo, CJ Meehan, W Mulders, I Cuella-Martin, L Rigouts, F Birembano, S Callens, BC de Jong, M Kaswa

Mycobacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of the Congo with primary resistance to delamanid and linezolid without treatment experience with these drugs. The identification of novel resistance mutations raises concerns about the potential global spread and poor outcomes of the WHO-recommended oral treatment regimens, highlighting the need for the urgent rollout of DST.

Original language	English
Article number	913
Journal	BMC Infectious Diseases
Volume	25
Number of pages	5
ISSN	1471-2334
DOIs	https://doi.org/10.1186/s12879-025-11348-w
Publication status	Published - 2025

Keywords

Drug resistance
Linezolid and Delamanid
Novel mutations

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10.1186/s12879-025-11348-wLicence: CC BY-NC-ND

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Bisimwa, BC., Bahizire, E., Kiselinova, M., Byela, V., Ngabonziza, JCS., Hakizayezu, F., Runyambo, D., Meehan, CJ., Mulders, W., Cuella-Martin, I., Rigouts, L., Birembano, F., Callens, S., de Jong, BC., & Kaswa, M. (2025). Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo. BMC Infectious Diseases, 25, Article 913. https://doi.org/10.1186/s12879-025-11348-w

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abstract = "The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of the Congo with primary resistance to delamanid and linezolid without treatment experience with these drugs. The identification of novel resistance mutations raises concerns about the potential global spread and poor outcomes of the WHO-recommended oral treatment regimens, highlighting the need for the urgent rollout of DST.",

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Bisimwa, BC, Bahizire, E, Kiselinova, M, Byela, V, Ngabonziza, JCS, Hakizayezu, F, Runyambo, D, Meehan, CJ, Mulders, W, Cuella-Martin, I, Rigouts, L, Birembano, F, Callens, S, de Jong, BC & Kaswa, M 2025, 'Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo', BMC Infectious Diseases, vol. 25, 913. https://doi.org/10.1186/s12879-025-11348-w

TY - JOUR

T1 - Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo

AU - Bisimwa, BC

AU - Bahizire, E

AU - Kiselinova, M

AU - Byela, V

AU - Ngabonziza, JCS

AU - Hakizayezu, F

AU - Runyambo, D

AU - Meehan, CJ

AU - Mulders, W

AU - Cuella-Martin, I

AU - Rigouts, L

AU - Birembano, F

AU - Callens, S

AU - de Jong, BC

AU - Kaswa, M

N1 - FTX: (CC BY NC ND)

PY - 2025

Y1 - 2025

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AB - The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of the Congo with primary resistance to delamanid and linezolid without treatment experience with these drugs. The identification of novel resistance mutations raises concerns about the potential global spread and poor outcomes of the WHO-recommended oral treatment regimens, highlighting the need for the urgent rollout of DST.

KW - Drug resistance

KW - Linezolid and Delamanid

KW - Novel mutations

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DO - 10.1186/s12879-025-11348-w

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C2 - 40652177

SN - 1471-2334

VL - 25

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

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Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo

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