Abstract
Three Beagle dogs were monitored clinically and serologically for 55 weeks following an experimental primo-infection and two challenge infections with a heterologous strain of Babesia canis.
There was no cross-protection when dogs were challenged with the heterologous strain after 7 months, but there was complete protection when challenged a second time with this heterologous strain 5 months later.
Although the serological profile using indirect immunofluorescence showed the same trend whether homologous or heterologous antigen was used, antibody titres generally reached higher values for homologous antigen. Seropositivity in itself was no guarantee for protective immunity against heterologous challenge.
There was no cross-protection when dogs were challenged with the heterologous strain after 7 months, but there was complete protection when challenged a second time with this heterologous strain 5 months later.
Although the serological profile using indirect immunofluorescence showed the same trend whether homologous or heterologous antigen was used, antibody titres generally reached higher values for homologous antigen. Seropositivity in itself was no guarantee for protective immunity against heterologous challenge.
| Original language | English |
|---|---|
| Journal | Veterinary Parasitology |
| Volume | 68 |
| Issue number | 1-2 |
| Pages (from-to) | 51-55 |
| Number of pages | 5 |
| ISSN | 0304-4017 |
| DOIs | |
| Publication status | Published - 1997 |
Keywords
- B780-tropical-medicine
- Animal diseases
- Dogs
- Protozoal diseases
- Babesiosis
- Babesia canis
- Fluorescent antibody technique
- IFAT
- Disease resistance