Dynamics and outcomes of Plasmodium infections in Grammomys surdaster (Grammomys dolichurus) thicket rats versus inbred mice

Solomon Conteh, Jacqueline Kolasny, Yvette L Robbins, Pati Pyana, Philippe Büscher, Javonn Musgrove, Brandi Butler, Lynn Lambert, John Patrick Gorres, Patrick E Duffy

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    Abstract

    Investigations of malaria infection are often conducted by studying rodent Plasmodium species in inbred laboratory mice, but the efficacy of vaccines or adjunctive therapies observed in these models often does not translate to protection in humans. This raises concerns that mouse malaria models do not recapitulate important features of human malaria infections. African woodland thicket rats (Grammomys surdaster) are the natural host for the rodent malaria parasite Plasmodium berghei and the suspected natural host for Plasmodium vinckei vinckei. Previously, we reported that thicket rats are highly susceptible to diverse rodent parasite species, including P. berghei, Plasmodium yoelii, and Plasmodium chabaudi chabaudi, and are a more stringent model to assess the efficacy of whole-sporozoite vaccines than laboratory mice. Here, we compare the course of infection and virulence with additional rodent Plasmodium species, including various strains of P. berghei, P. yoelii, P. chabaudi, and P. vinckei, in thicket rats versus laboratory mice. We present evidence that rodent malaria parasite growth typically differs between the natural versus nonnatural host; G. surdaster limit infection by multiple rodent malaria strains, delaying and reducing peak parasitemia compared with laboratory mice. The course of malaria infection in thicket rats varied depending on parasite species and strain, resulting in self-cure, chronic parasitemia, or rapidly lethal infection, thus offering a variety of rodent malaria models to study different clinical outcomes in the natural host.

    Original languageEnglish
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume103
    Issue number5
    Pages (from-to)1893-1901
    Number of pages9
    ISSN0002-9637
    DOIs
    Publication statusPublished - 2020

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