TY - JOUR
T1 - Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients
AU - Bwaka, MA
AU - Bonnet, MJ
AU - Calain, P
AU - Colebunders, R
AU - De Roo, A
AU - Guimard, Y
AU - Katwiki, KR
AU - Kibadi, K
AU - Kipasa, MA
AU - Kuvula, KJ
AU - Mapanda, BB
AU - Massamba, M
AU - Mupapa, KD
AU - Muyembe-Tamfum, JJ
AU - Ndaberey, E
AU - Peters, CJ
AU - Rollin, PE
AU - Van den Enden, E
N1 - FTX: Abonnement
PY - 1999
Y1 - 1999
N2 - During the 1995 outbreak of Ebola hemorrhagic fever in the Democratic Republic of the Congo, a series of 103 cases (one-third of the total number of cases) had clinical symptoms and signs accurately recorded by medical workers, mainly in the setting of the urban hospital in Kikwit. Clinical diagnosis was confirmed retrospectively in cases for which serum samples were available (n = 63,61% of the cases). The disease began unspecifically with fever, asthenia, diarrhea, headaches, myalgia, arthralgia, vomiting, and abdominal pain. Early inconsistent signs and symptoms included conjunctival injection, sore throat, and rash. Overall, bleeding signs were observed in <45% of the cases. Typically, terminally ill patients presented with obtundation, anuria, shock, tachypnea, and normothermia. Late manifestations, most frequently arthralgia and ocular diseases, occurred in convalescent patients. This series is the most extensive number of cases of Ebola hemorrhagic fever observed during an outbreak.
AB - During the 1995 outbreak of Ebola hemorrhagic fever in the Democratic Republic of the Congo, a series of 103 cases (one-third of the total number of cases) had clinical symptoms and signs accurately recorded by medical workers, mainly in the setting of the urban hospital in Kikwit. Clinical diagnosis was confirmed retrospectively in cases for which serum samples were available (n = 63,61% of the cases). The disease began unspecifically with fever, asthenia, diarrhea, headaches, myalgia, arthralgia, vomiting, and abdominal pain. Early inconsistent signs and symptoms included conjunctival injection, sore throat, and rash. Overall, bleeding signs were observed in <45% of the cases. Typically, terminally ill patients presented with obtundation, anuria, shock, tachypnea, and normothermia. Late manifestations, most frequently arthralgia and ocular diseases, occurred in convalescent patients. This series is the most extensive number of cases of Ebola hemorrhagic fever observed during an outbreak.
KW - B780-tropical-medicine
KW - Viral diseases
KW - Ebola virus disease
KW - Clinical medicine
KW - Case reports
KW - Kikwit
KW - Congo-Kinshasa
KW - Africa-Central
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000078400300002
U2 - 10.1086/514308
DO - 10.1086/514308
M3 - A1: Web of Science-article
SN - 0022-1899
VL - 179
SP - S1-S7
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - Suppl.1
ER -