Effect of bovine lactoferrin on prevention of late-onset sepsis in infants: a pooled analysis of individual patient data from two randomized controlled trials

Theresa J Ochoa, Sebastian Loli, Karina Mendoza, Cesar Carcamo, Sicilia Bellomo, Luis Cam, Anne Castañeda, Miguel Campos, Jan Jacobs, Veerle Cossey, Jaime Zegarra

Research output: Contribution to journalA1: Web of Science-article

Abstract

We previously conducted two randomized controlled trials of bovine lactoferrin (bLF) for prevention of late-onset sepsis (LOS) in infants with a birth weight <2500g (Study 1) and <2000g (Study 2). The aim of this study was to determine the effect of bLF on prevention of culture-proven or probable LOS in infants with a birth weight <1500g from both studies, and to determine the bLF effect depending on human milk intake. Both trial designs had similar inclusion and exclusion criteria, same bLF dose (200mg/kg/day) and same control (maltodextrin). We fitted multivariate Cox regression models to estimate the effect of bLF on the risk of development of the composite outcome, adjusting for covariates. We included 335 neonates with a mean birth weight of 1162g ±244g; 27.5% were <1000g. There were 33 first episodes of LOS in the bLF group and 48 in the control group (19.5% vs 28.9%). bLF had a protective effect on the risk of development LOS, Hazard Ratio (HR) 0.64 (%95CI: 0.41-0.99,p=0.048); particularly among infants <1000g, HR 0.46 (%95CI: 0.22-0.96,p=0.039) and among infants with low human milk intake, HR 0.40 (%95CI: 0.19-0.84,p=0.015). bLF supplementation protects against LOS in infants <1500g, especially among infants not receiving human milk.

Original languageEnglish
JournalBiochemistry and Cell Biology = Biochimie et Biologie Cellulaire
ISSN0829-8211
DOIs
Publication statusE-pub ahead of print - 2020

Fingerprint Dive into the research topics of 'Effect of bovine lactoferrin on prevention of late-onset sepsis in infants: a pooled analysis of individual patient data from two randomized controlled trials'. Together they form a unique fingerprint.

Cite this