Abstract
Background
There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition.
Methods
In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m2).
Results
The median BMI increase in DTG-based patients was 1.09 (IQR:-0.28,3.28) kg/m2 compared to 0.20 (IQR:-0.85,2.18) kg/m2 in EFV-based patients (p value = 0.001). DTG-based ART predicted excessive weight gain (aOR 2.61;95% CI:1.39–4.93).
Conclusion
Practitioners should consider DTG-based regimens as one of the risk factors for overweight/obesity.
There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition.
Methods
In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m2).
Results
The median BMI increase in DTG-based patients was 1.09 (IQR:-0.28,3.28) kg/m2 compared to 0.20 (IQR:-0.85,2.18) kg/m2 in EFV-based patients (p value = 0.001). DTG-based ART predicted excessive weight gain (aOR 2.61;95% CI:1.39–4.93).
Conclusion
Practitioners should consider DTG-based regimens as one of the risk factors for overweight/obesity.
| Original language | English |
|---|---|
| Article number | 4 |
| Journal | AIDS Research and Therapy |
| Volume | 21 |
| Issue number | 1 |
| Number of pages | 5 |
| ISSN | 1742-6405 |
| DOIs | |
| Publication status | Published - 2024 |
Keywords
- Dolutegravir
- Efavirenz
- Excessive weight gain
- Matsanjeni health centre