Electrolyte and metabolic disturbances in Ebola patients during a clinical trial, Guinea, 2015

Johan van Griensven; Elhadj Ibrahima Bah; Nyankoye Haba; Alexandre Delamou; Bienvenu Salim Camara; Kadio Jean-Jacques Olivier; Hilde De Clerck; Helena Nordenstedt; Malcolm G Semple; Michel Van Herp; Jozefien Buyze; Maaike De Crop; Steven Van Den Broucke; Lutgarde Lynen; Anja De Weggheleire; Ebola-Tx Consortium

doi:10.3201/eid2212.161136

Electrolyte and metabolic disturbances in Ebola patients during a clinical trial, Guinea, 2015

Johan van Griensven, Elhadj Ibrahima Bah, Nyankoye Haba, Alexandre Delamou, Bienvenu Salim Camara, Kadio Jean-Jacques Olivier, Hilde De Clerck, Helena Nordenstedt, Malcolm G Semple, Michel Van Herp, Jozefien Buyze, Maaike De Crop, Steven Van Den Broucke, Lutgarde Lynen, Anja De Weggheleire, Ebola-Tx Consortium

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Abstract

By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. Patients underwent testing with a point-of-care device. We used logistic regression to construct a prognostic model and summarized the predictive value with the area under the receiver operating curve. Abnormalities were common among patients, particularly hypokalemia, hypocalcemia, hyponatremia, raised creatinine, high anion gap, and anemia. Besides age and PCR cycle threshold value, renal dysfunction, low calcium levels, and low hemoglobin levels were independently associated with increased risk for death. A prognostic model using all 5 factors was highly discriminatory (area under the receiver operating curve 0.95; 95% CI 0.90-0.99) and enabled the definition of risk criteria to guide targeted care. Most patients had a very low (<5%) or very high (>80%) risk for death.

Original language	English
Journal	Emerging Infectious Diseases
Volume	22
Issue number	12
Pages (from-to)	2120-2127
Number of pages	8
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2212.161136
Publication status	Published - 2016

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van Griensven, J., Bah, E. I., Haba, N., Delamou, A., Camara, B. S., Olivier, K. J.-J., De Clerck, H., Nordenstedt, H., Semple, M. G., Van Herp, M., Buyze, J., De Crop, M., Van Den Broucke, S., Lynen, L., De Weggheleire, A., & Ebola-Tx Consortium (2016). Electrolyte and metabolic disturbances in Ebola patients during a clinical trial, Guinea, 2015. Emerging Infectious Diseases, 22(12), 2120-2127. https://doi.org/10.3201/eid2212.161136

@article{51a34109d80043adb11112bba9778f36,

title = "Electrolyte and metabolic disturbances in Ebola patients during a clinical trial, Guinea, 2015",

abstract = "By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. Patients underwent testing with a point-of-care device. We used logistic regression to construct a prognostic model and summarized the predictive value with the area under the receiver operating curve. Abnormalities were common among patients, particularly hypokalemia, hypocalcemia, hyponatremia, raised creatinine, high anion gap, and anemia. Besides age and PCR cycle threshold value, renal dysfunction, low calcium levels, and low hemoglobin levels were independently associated with increased risk for death. A prognostic model using all 5 factors was highly discriminatory (area under the receiver operating curve 0.95; 95% CI 0.90-0.99) and enabled the definition of risk criteria to guide targeted care. Most patients had a very low (<5%) or very high (>80%) risk for death.",

author = "{van Griensven}, Johan and Bah, {Elhadj Ibrahima} and Nyankoye Haba and Alexandre Delamou and Camara, {Bienvenu Salim} and Olivier, {Kadio Jean-Jacques} and {De Clerck}, Hilde and Helena Nordenstedt and Semple, {Malcolm G} and {Van Herp}, Michel and Jozefien Buyze and {De Crop}, Maaike and {Van Den Broucke}, Steven and Lutgarde Lynen and {De Weggheleire}, Anja and {Ebola-Tx Consortium}",

note = "FTX; DOAJ",

year = "2016",

doi = "10.3201/eid2212.161136",

language = "English",

volume = "22",

pages = "2120--2127",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "12",

}

van Griensven, J, Bah, EI, Haba, N, Delamou, A, Camara, BS, Olivier, KJ-J, De Clerck, H, Nordenstedt, H, Semple, MG, Van Herp, M, Buyze, J, De Crop, M, Van Den Broucke, S , Lynen, L, De Weggheleire, A & Ebola-Tx Consortium 2016, 'Electrolyte and metabolic disturbances in Ebola patients during a clinical trial, Guinea, 2015', Emerging Infectious Diseases, vol. 22, no. 12, pp. 2120-2127. https://doi.org/10.3201/eid2212.161136

TY - JOUR

T1 - Electrolyte and metabolic disturbances in Ebola patients during a clinical trial, Guinea, 2015

AU - van Griensven, Johan

AU - Bah, Elhadj Ibrahima

AU - Haba, Nyankoye

AU - Delamou, Alexandre

AU - Camara, Bienvenu Salim

AU - Olivier, Kadio Jean-Jacques

AU - De Clerck, Hilde

AU - Nordenstedt, Helena

AU - Semple, Malcolm G

AU - Van Herp, Michel

AU - Buyze, Jozefien

AU - De Crop, Maaike

AU - Van Den Broucke, Steven

AU - Lynen, Lutgarde

AU - De Weggheleire, Anja

AU - Ebola-Tx Consortium

N1 - FTX; DOAJ

PY - 2016

Y1 - 2016

N2 - By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. Patients underwent testing with a point-of-care device. We used logistic regression to construct a prognostic model and summarized the predictive value with the area under the receiver operating curve. Abnormalities were common among patients, particularly hypokalemia, hypocalcemia, hyponatremia, raised creatinine, high anion gap, and anemia. Besides age and PCR cycle threshold value, renal dysfunction, low calcium levels, and low hemoglobin levels were independently associated with increased risk for death. A prognostic model using all 5 factors was highly discriminatory (area under the receiver operating curve 0.95; 95% CI 0.90-0.99) and enabled the definition of risk criteria to guide targeted care. Most patients had a very low (<5%) or very high (>80%) risk for death.

AB - By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. Patients underwent testing with a point-of-care device. We used logistic regression to construct a prognostic model and summarized the predictive value with the area under the receiver operating curve. Abnormalities were common among patients, particularly hypokalemia, hypocalcemia, hyponatremia, raised creatinine, high anion gap, and anemia. Besides age and PCR cycle threshold value, renal dysfunction, low calcium levels, and low hemoglobin levels were independently associated with increased risk for death. A prognostic model using all 5 factors was highly discriminatory (area under the receiver operating curve 0.95; 95% CI 0.90-0.99) and enabled the definition of risk criteria to guide targeted care. Most patients had a very low (<5%) or very high (>80%) risk for death.

U2 - 10.3201/eid2212.161136

DO - 10.3201/eid2212.161136

M3 - A1: Web of Science-article

C2 - 27869610

SN - 1080-6040

VL - 22

SP - 2120

EP - 2127

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 12

ER -

Electrolyte and metabolic disturbances in Ebola patients during a clinical trial, Guinea, 2015

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