@article{5882dddec9f84b5a8c8dd940a9cbdc46,
title = "In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso",
abstract = "Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.",
keywords = "Antimanic Agents, Artemisinins, Burkina Faso, Drug Combinations, Drug Resistance, Ethanolamines, Fluorenes, Genetic Variation, Humans, Malaria, Falciparum, Membrane Transport Proteins, Multidrug Resistance-Associated Proteins, Plasmodium falciparum, Protozoan Proteins, Quinolines",
author = "Vito Baraka and Halidou Tinto and Innocent Valea and Robert Fitzhenry and Christopher Delgado-Ratto and Mbonye, {Martin K} and {Van Overmeir}, Chantal and Anna Rosanas-Urgell and {Van Geertruyden}, Jean-Pierre and Umberto D'Alessandro and Annette Erhart",
note = "Copyright {\textcopyright} 2015, American Society for Microbiology. All Rights Reserved.",
year = "2015",
doi = "10.1128/AAC.03647-14",
language = "English",
volume = "59",
pages = "734--737",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "1",
}