In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso

Vito Baraka; Halidou Tinto; Innocent Valea; Robert Fitzhenry; Christopher Delgado-Ratto; Martin K Mbonye; Chantal Van Overmeir; Anna Rosanas-Urgell; Jean-Pierre Van Geertruyden; Umberto D'Alessandro; Annette Erhart

doi:10.1128/AAC.03647-14

In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso

Vito Baraka
, Halidou Tinto
, Innocent Valea
, Robert Fitzhenry
, Christopher Delgado-Ratto
, Martin K Mbonye
, Chantal Van Overmeir
, Anna Rosanas-Urgell
, Jean-Pierre Van Geertruyden
, Umberto D'Alessandro
, Annette Erhart

Malariology

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

Abstract

Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	1
Pages (from-to)	734-737
Number of pages	4
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.03647-14
Publication status	Published - 2015

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10.1128/AAC.03647-14

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Baraka, V., Tinto, H., Valea, I., Fitzhenry, R., Delgado-Ratto, C., Mbonye, M. K., Van Overmeir, C., Rosanas-Urgell, A., Van Geertruyden, J.-P., D'Alessandro, U., & Erhart, A. (2015). In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso. Antimicrobial Agents and Chemotherapy, 59(1), 734-737. https://doi.org/10.1128/AAC.03647-14

@article{5882dddec9f84b5a8c8dd940a9cbdc46,

title = "In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso",

abstract = "Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.",

keywords = "Antimanic Agents, Artemisinins, Burkina Faso, Drug Combinations, Drug Resistance, Ethanolamines, Fluorenes, Genetic Variation, Humans, Malaria, Falciparum, Membrane Transport Proteins, Multidrug Resistance-Associated Proteins, Plasmodium falciparum, Protozoan Proteins, Quinolines",

author = "Vito Baraka and Halidou Tinto and Innocent Valea and Robert Fitzhenry and Christopher Delgado-Ratto and Mbonye, \{Martin K\} and \{Van Overmeir\}, Chantal and Anna Rosanas-Urgell and \{Van Geertruyden\}, Jean-Pierre and Umberto D'Alessandro and Annette Erhart",

year = "2015",

doi = "10.1128/AAC.03647-14",

language = "English",

volume = "59",

pages = "734--737",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "1",

}

Baraka, V, Tinto, H, Valea, I, Fitzhenry, R, Delgado-Ratto, C, Mbonye, MK, Van Overmeir, C, Rosanas-Urgell, A, Van Geertruyden, J-P, D'Alessandro, U & Erhart, A 2015, 'In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso', Antimicrobial Agents and Chemotherapy, vol. 59, no. 1, pp. 734-737. https://doi.org/10.1128/AAC.03647-14

In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso. / Baraka, Vito; Tinto, Halidou; Valea, Innocent et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 1, 2015, p. 734-737.

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

TY - JOUR

T1 - In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso

AU - Baraka, Vito

AU - Tinto, Halidou

AU - Valea, Innocent

AU - Fitzhenry, Robert

AU - Delgado-Ratto, Christopher

AU - Mbonye, Martin K

AU - Van Overmeir, Chantal

AU - Rosanas-Urgell, Anna

AU - Van Geertruyden, Jean-Pierre

AU - D'Alessandro, Umberto

AU - Erhart, Annette

PY - 2015

Y1 - 2015

N2 - Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.

AB - Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.

KW - Antimanic Agents

KW - Artemisinins

KW - Burkina Faso

KW - Drug Combinations

KW - Drug Resistance

KW - Ethanolamines

KW - Fluorenes

KW - Genetic Variation

KW - Humans

KW - Malaria, Falciparum

KW - Membrane Transport Proteins

KW - Multidrug Resistance-Associated Proteins

KW - Plasmodium falciparum

KW - Protozoan Proteins

KW - Quinolines

U2 - 10.1128/AAC.03647-14

DO - 10.1128/AAC.03647-14

M3 - A1: Peer-reviewed journal articles

C2 - 25403659

SN - 0066-4804

VL - 59

SP - 734

EP - 737

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 1

ER -

In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso

Abstract

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