Mycobacterium africanum--review of an important cause of human tuberculosis in West Africa

BC de Jong, M Antonio, S Gagneux

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. In this review we discuss the definition of M. africanum, describe the prevalence and restricted geographical distribution of M. africanum West African 1 and 2, review the occurrence of M. africanum in animals, and summarize the phenotypic differences described thus far between M. africanum and M. tuberculosis sensu stricto
    Original languageEnglish
    JournalPLoS Neglected Tropical Diseases
    Volume4
    Issue number9
    Pages (from-to)e744
    Number of pages9
    ISSN1935-2727
    DOIs
    Publication statusPublished - 2010

    Keywords

    • B780-tropical-medicine
    • Bacterial diseases
    • Pulmonary
    • Tuberculosis
    • Mycobacterium africanum
    • Mycobacterium tuberculosis
    • Prevalence
    • Epidemiology
    • Phylogeny
    • Case definition
    • Nomenclature
    • Geographical distribution
    • Occurrence
    • Phenotypes
    • Clinical manifestations
    • Review of the literature

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