Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

David Stucki, Daniela Brites, Leila Jeljeli, Mireia Coscolla, Qingyun Liu, Andrej Trauner, Lukas Fenner, Liliana Rutaihwa, Sonia Borrell, Tao Luo, Qian Gao, Midori Kato-Maeda, Marie Ballif, Matthias Egger, Rita Macedo, Helmi Mardassi, Milagros Moreno, Griselda Tudo Vilanova, Janet Fyfe, Maria GlobanJackson Thomas, Frances Jamieson, Jennifer L. Guthrie, Adwoa Asante-Poku, Dorothy Yeboah-Manu, Eddie Wampande, Willy Ssengooba, Moses Joloba, W. Henry Boom, Indira Basu, James Bower, Margarida Saraiva, Sidra E. G. Vasconcellos, Philip Suffys, Anastasia Koch, Robert Wilkinson, Linda Gail-Bekker, Bijaya Malla, Serej D. Ley, Hans-Peter Beck, Bouke C. de Jong, Kadri Toit, Elisabeth Sanchez-Padilla, Maryline Bonnet, Ana Gil-Brusola, Matthias Frank, Veronique N. Penlap Beng, Kathleen Eisenach, Florian Gehre, Francesca Barletta

Research output: Contribution to journalA1: Web of Science-article

Abstract

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.

Original languageEnglish
JournalNature Genetics
Volume48
Issue number12
Pages (from-to)1535-1543
Number of pages9
ISSN1061-4036
DOIs
Publication statusPublished - 2016

Keywords

  • PAPUA-NEW-GUINEA
  • GENETIC DIVERSITY
  • RESISTANT TUBERCULOSIS
  • ANTIGENIC VARIATION
  • GENOMIC DIVERSITY
  • HIV-INFECTION
  • SOUTH-AFRICA
  • POPULATION
  • PATHOGENS
  • EVOLUTION

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