Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure

E Ochong; DJ Bell; DJ Johnson; Umberto D'Alessandro; M Mulenga; S Muangnoicharoen; Jean-Pierre Van Geertruyden; PA Winstanley; PG Bray; SA Ward; A Owen

doi:10.1128/AAC.00431-08

Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure

E Ochong, DJ Bell, DJ Johnson, Umberto D'Alessandro, M Mulenga, S Muangnoicharoen, Jean-Pierre Van Geertruyden, PA Winstanley, PG Bray, SA Ward, A Owen

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	11
Pages (from-to)	3883-3888
Number of pages	6
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.00431-08
Publication status	Published - 2008

Keywords

B780-tropical-medicine
Protozoal diseases
Malaria
Plasmodium falciparum
Antimalarials
Pyrimethamine
Chlorproguanil
Drug resistance
Mutations
Dihydrofolate reductase
Prevalence
Reliability
Malawi
Zambia
Africa-Southern

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10.1128/AAC.00431-08Licence: Unspecified

http://lib.itg.be/pdf/itg/2008/2008aach3883.pdfLicence: Unspecified

Cite this

Ochong, E., Bell, DJ., Johnson, DJ., D'Alessandro, U., Mulenga, M., Muangnoicharoen, S., Van Geertruyden, J.-P., Winstanley, PA., Bray, PG., Ward, SA., & Owen, A. (2008). Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure. Antimicrobial Agents and Chemotherapy, 52(11), 3883-3888. https://doi.org/10.1128/AAC.00431-08

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title = "Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure",

keywords = "B780-tropical-medicine, Protozoal diseases, Malaria, Plasmodium falciparum, Antimalarials, Pyrimethamine, Chlorproguanil, Drug resistance, Mutations, Dihydrofolate reductase, Prevalence, Reliability, Malawi, Zambia, Africa-Southern",

author = "E Ochong and DJ Bell and DJ Johnson and Umberto D'Alessandro and M Mulenga and S Muangnoicharoen and {Van Geertruyden}, Jean-Pierre and PA Winstanley and PG Bray and SA Ward and A Owen",

note = "ITG-P4A; ITG-P7A; PARAS; U-MALAR; JIF; DOI; PDF; DSPACE",

year = "2008",

doi = "10.1128/AAC.00431-08",

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Ochong, E, Bell, DJ, Johnson, DJ, D'Alessandro, U, Mulenga, M, Muangnoicharoen, S, Van Geertruyden, J-P, Winstanley, PA, Bray, PG, Ward, SA & Owen, A 2008, 'Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure', Antimicrobial Agents and Chemotherapy, vol. 52, no. 11, pp. 3883-3888. https://doi.org/10.1128/AAC.00431-08

TY - JOUR

T1 - Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure

AU - Ochong, E

AU - Bell, DJ

AU - Johnson, DJ

AU - D'Alessandro, Umberto

AU - Mulenga, M

AU - Muangnoicharoen, S

AU - Van Geertruyden, Jean-Pierre

AU - Winstanley, PA

AU - Bray, PG

AU - Ward, SA

AU - Owen, A

N1 - ITG-P4A; ITG-P7A; PARAS; U-MALAR; JIF; DOI; PDF; DSPACE

PY - 2008

Y1 - 2008

KW - B780-tropical-medicine

KW - Protozoal diseases

KW - Malaria

KW - Plasmodium falciparum

KW - Antimalarials

KW - Pyrimethamine

KW - Chlorproguanil

KW - Drug resistance

KW - Mutations

KW - Dihydrofolate reductase

KW - Prevalence

KW - Reliability

KW - Malawi

KW - Zambia

KW - Africa-Southern

U2 - 10.1128/AAC.00431-08

DO - 10.1128/AAC.00431-08

M3 - A1: Web of Science-article

SN - 0066-4804

VL - 52

SP - 3883

EP - 3888

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -