Trypanosoma brucei gambiense spliced leader RNA is a more specific marker for cure of human African trypanosomiasis than T. b. gambiense DNA

Hamidou Ilboudo, Oumou Camara, Sophie Ravel, Bruno Bucheton, Veerle Lejon, Mamadou Camara, Jacques Kaboré, Vincent Jamonneau, Stijn Deborggraeve

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    To assess the efficacy of treatment for human African trypanosomiasis, accurate tests that can discriminate relapse from cure are needed. We report the first data that the spliced leader (SL) RNA is a more specific marker for cure of human African trypanosomiasis than parasite DNA. In blood samples obtained from 61 patients in whom human African trypanosomiasis was cured, SL RNA detection had specificities of 98.4%-100%, while DNA detection had a specificity of only 77%. Data from our proof-of-concept study show that SL RNA detection has high potential as a test of cure.

    Original languageEnglish
    JournalJournal of Infectious Diseases
    Volume212
    Issue number12
    Pages (from-to)1996-1998
    Number of pages3
    ISSN0022-1899
    DOIs
    Publication statusPublished - 2015

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