Enhancing tsetse fly refractoriness to trypanosome infection - a new IAEA coordinated research project

J. Van Den Abbeele, K. Bourtzis, B. Weiss, C. Cordon-Rosales, W. Miller, A.M. Abd-Alla, A. Parker

Research output: Contribution to journalA1: Web of Science-article

Abstract

To date, IAEA-supported Sterile Insect Technique (SIT) projects for tsetse and trypanosomiasis control have been in areas without human sleeping sickness, but future projects could include areas of actual or potential human disease transmission. In this context it would be imperative that released sterile tsetse flies are incompetent to transmit the disease-causing trypanosome parasite. Therefore, development of tsetse fly strains refractory to trypanosome infection is highly desirable as a simple and effective method of ensuring vector incompetence of the released flies. This new IAEA Coordinated Research Project (CRP) focuses on gaining a deeper knowledge of the tripartite interactions between the tsetse fly vectors, their symbionts and trypanosome parasites. The objective of this CRP is to acquire a better understanding of mechanisms that limit the development of trypanosome infections in tsetse and how these may be enhanced.
Original languageEnglish
JournalJournal of Invertebrate Pathology
Volume112
Issue numberS1
Pages (from-to)S142-S147
Number of pages6
DOIs
Publication statusPublished - 2013

Keywords

  • Protozoal diseases
  • Sleeping sickness
  • Trypanosomiasis-African
  • Nagana
  • Trypanosoma brucei gambiense
  • Vectors
  • Tsetse flies
  • Glossina morsitans
  • Control
  • Sterile insect technique
  • Molecular cloning
  • Strains
  • Vectorial competence
  • Symbionts
  • Research
  • Host-parasite relationship
  • Review of the literature

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