Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

Henry M. Kariithi; Irene K. Meki; Daniela I. Schneider; Linda De Vooght; Fathiya M. Khamis; Anne Geiger; Guler Demirbas-Uzel; Just M. Vlak; Ikbal Agah Ince; Sorge Kelm; Flobert Njiokou; Florence N. Wamwiri; Imna I. Malele; Brian L. Weiss; Adly M. M. Abd-Alla

doi:10.1186/s12866-018-1280-y

Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

Henry M. Kariithi, Irene K. Meki, Daniela I. Schneider, Linda De Vooght, Fathiya M. Khamis, Anne Geiger, Guler Demirbas-Uzel, Just M. Vlak, Ikbal Agah Ince, Sorge Kelm, Flobert Njiokou, Florence N. Wamwiri, Imna I. Malele, Brian L. Weiss, Adly M. M. Abd-Alla

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Abstract

With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

Original language	English
Article number	179
Journal	BMC Microbiology
Volume	18
Number of pages	13
ISSN	1471-2180
DOIs	https://doi.org/10.1186/s12866-018-1280-y
Publication status	Published - 2018

Keywords

Glossina
Microbiota
Paratransgenesis
Vector competence
Trypanosoma-refractoriness
sterile insect technique
Hytrosaviridae
GLOSSINA-PALPALIS-GAMBIENSIS
SALIVARY-GLAND HYPERTROPHY
SLEEPING SICKNESS FOCI
CONGOLENSE FOREST TYPE
TSETSE-FLIES DIPTERA
SODALIS-GLOSSINIDIUS
LABORATORY COLONIES
MORSITANS VECTOR
HOST PREFERENCE
MUSCA-DOMESTICA

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Kariithi, H. M., Meki, I. K., Schneider, D. I., De Vooght, L., Khamis, F. M., Geiger, A., Demirbas-Uzel, G., Vlak, J. M., Ince, I. A., Kelm, S., Njiokou, F., Wamwiri, F. N., Malele, I. I., Weiss, B. L., & Abd-Alla, A. M. M. (2018). Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives. BMC Microbiology, 18, Article 179. https://doi.org/10.1186/s12866-018-1280-y

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abstract = "With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.",

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author = "Kariithi, {Henry M.} and Meki, {Irene K.} and Schneider, {Daniela I.} and {De Vooght}, Linda and Khamis, {Fathiya M.} and Anne Geiger and Guler Demirbas-Uzel and Vlak, {Just M.} and Ince, {Ikbal Agah} and Sorge Kelm and Flobert Njiokou and Wamwiri, {Florence N.} and Malele, {Imna I.} and Weiss, {Brian L.} and Abd-Alla, {Adly M. M.}",

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AU - Kariithi, Henry M.

AU - Meki, Irene K.

AU - Schneider, Daniela I.

AU - De Vooght, Linda

AU - Khamis, Fathiya M.

AU - Geiger, Anne

AU - Demirbas-Uzel, Guler

AU - Vlak, Just M.

AU - Ince, Ikbal Agah

AU - Kelm, Sorge

AU - Njiokou, Flobert

AU - Wamwiri, Florence N.

AU - Malele, Imna I.

AU - Weiss, Brian L.

AU - Abd-Alla, Adly M. M.

N1 - FTX; DOAJ

PY - 2018

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N2 - With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

AB - With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

KW - Glossina

KW - Microbiota

KW - Paratransgenesis

KW - Vector competence

KW - Trypanosoma-refractoriness

KW - sterile insect technique

KW - Hytrosaviridae

KW - GLOSSINA-PALPALIS-GAMBIENSIS

KW - SALIVARY-GLAND HYPERTROPHY

KW - SLEEPING SICKNESS FOCI

KW - CONGOLENSE FOREST TYPE

KW - TSETSE-FLIES DIPTERA

KW - SODALIS-GLOSSINIDIUS

KW - LABORATORY COLONIES

KW - MORSITANS VECTOR

KW - HOST PREFERENCE

KW - MUSCA-DOMESTICA

U2 - 10.1186/s12866-018-1280-y

DO - 10.1186/s12866-018-1280-y

M3 - A1: Web of Science-article

SN - 1471-2180

VL - 18

JO - BMC Microbiology

JF - BMC Microbiology

M1 - 179

ER -

Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

Abstract

Keywords

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