Estimated incidence of influenza-virus-associated severe pneumonia in children in El Salvador, 2008-2010

Wilfrido Clara, Julio Armero, David Rodriguez, Celina de Lozano, Luis Bonilla, Percy Minaya, Rafael Chacón, Jorge Jara, Natalia Blanco, Marc-Alain Widdowson, Joseph Bresee, Xiyan Xu, Alexander Klimov, Eduardo Azziz-Baumgartner, Nivaldo Linares-Perez

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To estimate the incidence of influenza-virus-associated severe pneumonia among Salvadorian children aged < 5 years.

METHODS: Data on children aged < 5 years admitted with severe pneumonia to a sentinel hospital in the western region were collected weekly. Nasal and oropharyngeal swab specimens were collected from a convenience sample of case patients for respiratory virus testing. A health-care utilization survey was conducted in the hospital catchment area to determine the proportion of residents who sought care at the hospital. The incidence of influenza-virus-associated severe pneumonia among all Salvadorian children aged < 5 years was estimated from surveillance and census data, with adjustment for health-care utilization. Influenza virus strains were characterized by the United States Centers for Disease Control and Prevention to determine their correspondence with northern and southern hemisphere influenza vaccine formulations.

FINDINGS: Physicians identified 2554 cases of severe pneumonia. Samples from 608 cases were tested for respiratory viruses and 37 (6%) were positive for influenza virus. The estimated incidence of influenza-virus-associated severe pneumonia was 3.2 cases per 1000 person-years (95% confidence interval, CI: 2.8-3.7) overall, 1.5 cases per 1000 person-years (95% CI: 1.0-2.0) during 2008, 7.6 cases per 1000 person-years (95% CI: 6.5-8.9) during 2009 and 0.6 cases per 1000 person-years (95% CI: 0.3-1.0) during 2010. Northern and southern hemisphere vaccine formulations matched influenza virus strains isolated during 2008 and 2010.

CONCLUSION: Influenza-virus-associated severe pneumonia occurred frequently among young Salvadorian children during 2008-2010. Antigens in northern and southern hemisphere influenza vaccine formulations corresponded to circulating strains.

Original languageEnglish
JournalBulletin of the World Health Organization
Volume90
Issue number10
Pages (from-to)756-63
Number of pages8
ISSN0042-9686
DOIs
Publication statusPublished - 2012

Keywords

  • Child, Preschool
  • El Salvador/epidemiology
  • Female
  • Humans
  • Incidence
  • Infant
  • Influenza A Virus, H1N1 Subtype/isolation & purification
  • Influenza, Human/complications
  • Male
  • Mucus/virology
  • Pneumonia, Viral/epidemiology
  • Severity of Illness Index

Fingerprint Dive into the research topics of 'Estimated incidence of influenza-virus-associated severe pneumonia in children in El Salvador, 2008-2010'. Together they form a unique fingerprint.

Cite this