Evaluation of a clinical case-definition of acquired immunodeficiency syndrome in Africa

R Colebunders, JM Mann, H Francis, B Kapita, I Lebughe, K Ndangi, K Kanyinda, I Limbaka, N Nzilambi, TC Quinn, G van der Groen, JW Curran, G Vercauteren, P Piot

Research output: Contribution to journalA2: International peer reviewed article (not A1-type)

Abstract

A provisional clinical case-definition for acquired immunodeficiency syndrome (AIDS) developed by the World Health Organisation (WHO) for use in Africa was tested on 174 inpatients at Mama Yemo Hospital, Kinshasa, Zaire. In this hospital population with a 34% infection rate of human immunodeficiency virus (HIV), the clinical case-definition had a specificity of 90%, a sensitivity of 59%, and a predictive value of 74% for HIV seropositivity. These results support the use of the WHO clinical definition for AIDS in Africa. However, since HIV prevalence and disease expression vary, similar evaluations should be carried out in different regions
Original languageEnglish
JournalLancet
Volumei
Pages (from-to)492-494
ISSN0140-6736
Publication statusPublished - 1987

Keywords

  • B780-tropical-medicine
  • AIDS
  • Viral diseases
  • Diagnosis
  • Epidemiology
  • Antibodies
  • Hospitalization
  • Probability
  • Questionnaires
  • Tuberculosis
  • Bacterial diseases
  • World Health Organization (WHO)
  • WHO
  • Congo-Kinshasa
  • Africa-Central

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