Evaluation of a clinical case-definition of acquired immunodeficiency syndrome in Africa

R Colebunders; JM Mann; H Francis; B Kapita; I Lebughe; K Ndangi; K Kanyinda; I Limbaka; N Nzilambi; TC Quinn; G van der Groen; JW Curran; G Vercauteren; P Piot

Evaluation of a clinical case-definition of acquired immunodeficiency syndrome in Africa

R Colebunders, JM Mann, H Francis, B Kapita, I Lebughe, K Ndangi, K Kanyinda, I Limbaka, N Nzilambi, TC Quinn, G van der Groen, JW Curran, G Vercauteren, P Piot

Institute of Tropical Medicine

Research output: Contribution to journal › A2: International peer reviewed article (not A1-type) › peer-review

Abstract

A provisional clinical case-definition for acquired immunodeficiency syndrome (AIDS) developed by the World Health Organisation (WHO) for use in Africa was tested on 174 inpatients at Mama Yemo Hospital, Kinshasa, Zaire. In this hospital population with a 34% infection rate of human immunodeficiency virus (HIV), the clinical case-definition had a specificity of 90%, a sensitivity of 59%, and a predictive value of 74% for HIV seropositivity. These results support the use of the WHO clinical definition for AIDS in Africa. However, since HIV prevalence and disease expression vary, similar evaluations should be carried out in different regions

Original language	English
Journal	Lancet
Volume	i
Pages (from-to)	492-494
ISSN	0140-6736
Publication status	Published - 1987

Keywords

B780-tropical-medicine
AIDS
Viral diseases
Diagnosis
Epidemiology
Antibodies
Hospitalization
Probability
Questionnaires
Tuberculosis
Bacterial diseases
World Health Organization (WHO)
WHO
Congo-Kinshasa
Africa-Central

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Cite this

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title = "Evaluation of a clinical case-definition of acquired immunodeficiency syndrome in Africa",

abstract = "A provisional clinical case-definition for acquired immunodeficiency syndrome (AIDS) developed by the World Health Organisation (WHO) for use in Africa was tested on 174 inpatients at Mama Yemo Hospital, Kinshasa, Zaire. In this hospital population with a 34% infection rate of human immunodeficiency virus (HIV), the clinical case-definition had a specificity of 90%, a sensitivity of 59%, and a predictive value of 74% for HIV seropositivity. These results support the use of the WHO clinical definition for AIDS in Africa. However, since HIV prevalence and disease expression vary, similar evaluations should be carried out in different regions",

keywords = "B780-tropical-medicine, AIDS, Viral diseases, Diagnosis, Epidemiology, Antibodies, Hospitalization, Probability, Questionnaires, Tuberculosis, Bacterial diseases, World Health Organization (WHO), WHO, Congo-Kinshasa, Africa-Central",

author = "R Colebunders and JM Mann and H Francis and B Kapita and I Lebughe and K Ndangi and K Kanyinda and I Limbaka and N Nzilambi and TC Quinn and {van der Groen}, G and JW Curran and G Vercauteren and P Piot",

year = "1987",

language = "English",

volume = "i",

pages = "492--494",

journal = "Lancet",

issn = "0140-6736",

publisher = "Elsevier",

}

TY - JOUR

T1 - Evaluation of a clinical case-definition of acquired immunodeficiency syndrome in Africa

AU - Colebunders, R

AU - Mann, JM

AU - Francis, H

AU - Kapita, B

AU - Lebughe, I

AU - Ndangi, K

AU - Kanyinda, K

AU - Limbaka, I

AU - Nzilambi, N

AU - Quinn, TC

AU - van der Groen, G

AU - Curran, JW

AU - Vercauteren, G

AU - Piot, P

PY - 1987

Y1 - 1987

N2 - A provisional clinical case-definition for acquired immunodeficiency syndrome (AIDS) developed by the World Health Organisation (WHO) for use in Africa was tested on 174 inpatients at Mama Yemo Hospital, Kinshasa, Zaire. In this hospital population with a 34% infection rate of human immunodeficiency virus (HIV), the clinical case-definition had a specificity of 90%, a sensitivity of 59%, and a predictive value of 74% for HIV seropositivity. These results support the use of the WHO clinical definition for AIDS in Africa. However, since HIV prevalence and disease expression vary, similar evaluations should be carried out in different regions

AB - A provisional clinical case-definition for acquired immunodeficiency syndrome (AIDS) developed by the World Health Organisation (WHO) for use in Africa was tested on 174 inpatients at Mama Yemo Hospital, Kinshasa, Zaire. In this hospital population with a 34% infection rate of human immunodeficiency virus (HIV), the clinical case-definition had a specificity of 90%, a sensitivity of 59%, and a predictive value of 74% for HIV seropositivity. These results support the use of the WHO clinical definition for AIDS in Africa. However, since HIV prevalence and disease expression vary, similar evaluations should be carried out in different regions

KW - B780-tropical-medicine

KW - AIDS

KW - Viral diseases

KW - Diagnosis

KW - Epidemiology

KW - Antibodies

KW - Hospitalization

KW - Probability

KW - Questionnaires

KW - Tuberculosis

KW - Bacterial diseases

KW - World Health Organization (WHO)

KW - WHO

KW - Congo-Kinshasa

KW - Africa-Central

M3 - A2: International peer reviewed article (not A1-type)

SN - 0140-6736

VL - i

SP - 492

EP - 494

JO - Lancet

JF - Lancet

ER -

Evaluation of a clinical case-definition of acquired immunodeficiency syndrome in Africa

Abstract

Keywords

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