Evaluation of a clinical case definition of AIDS in African children

RL Colebunders; A Greenberg; P Nguyen-Dinh; H Francis; N Kabote; I Lebughe; F Davachi; TC Quinn; P Piot

Evaluation of a clinical case definition of AIDS in African children

RL Colebunders, A Greenberg, P Nguyen-Dinh, H Francis, N Kabote, I Lebughe, F Davachi, TC Quinn, P Piot

Research output: Contribution to journal › A2: International peer reviewed article (not A1-type) › peer-review

Abstract

In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa, Zaire. Twenty-one (13%) of these children were seropositive for HIV. In this population, the clinical case definition of pediatric AIDS was found to be fairly specific (87%) but lacked sensitivity (35%). The positive predictive value for HIV seropositivity was 25%. This study suggests that it is more difficult to define AIDS clinically in children than in adults and that the utility of the proposed WHO clinical case definition for pediatric AIDS for surveillance of children's AIDS in Africa is limited

Original language	English
Journal	AIDS
Volume	1
Pages (from-to)	151-153
ISSN	0269-9370
Publication status	Published - 1987

Keywords

B780-tropical-medicine
Viral diseases
AIDS
Diagnosis
Immunology
Africa
Antibodies
Children
Diagnostic errors
Evaluation studies
Human
HIV
Infants
Case definition
Kinshasa
Congo-Kinshasa
Africa-Central

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@article{60e281d7517249a9a7e8ecc260ca7b25,

title = "Evaluation of a clinical case definition of AIDS in African children",

abstract = "In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa, Zaire. Twenty-one (13%) of these children were seropositive for HIV. In this population, the clinical case definition of pediatric AIDS was found to be fairly specific (87%) but lacked sensitivity (35%). The positive predictive value for HIV seropositivity was 25%. This study suggests that it is more difficult to define AIDS clinically in children than in adults and that the utility of the proposed WHO clinical case definition for pediatric AIDS for surveillance of children's AIDS in Africa is limited",

keywords = "B780-tropical-medicine, Viral diseases, AIDS, Diagnosis, Immunology, Africa, Antibodies, Children, Diagnostic errors, Evaluation studies, Human, HIV, Infants, Case definition, Kinshasa, Congo-Kinshasa, Africa-Central",

author = "RL Colebunders and A Greenberg and P Nguyen-Dinh and H Francis and N Kabote and I Lebughe and F Davachi and TC Quinn and P Piot",

year = "1987",

language = "English",

volume = "1",

pages = "151--153",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams & Wilkins",

}

TY - JOUR

T1 - Evaluation of a clinical case definition of AIDS in African children

AU - Colebunders, RL

AU - Greenberg, A

AU - Nguyen-Dinh, P

AU - Francis, H

AU - Kabote, N

AU - Lebughe, I

AU - Davachi, F

AU - Quinn, TC

AU - Piot, P

PY - 1987

Y1 - 1987

N2 - In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa, Zaire. Twenty-one (13%) of these children were seropositive for HIV. In this population, the clinical case definition of pediatric AIDS was found to be fairly specific (87%) but lacked sensitivity (35%). The positive predictive value for HIV seropositivity was 25%. This study suggests that it is more difficult to define AIDS clinically in children than in adults and that the utility of the proposed WHO clinical case definition for pediatric AIDS for surveillance of children's AIDS in Africa is limited

AB - In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa, Zaire. Twenty-one (13%) of these children were seropositive for HIV. In this population, the clinical case definition of pediatric AIDS was found to be fairly specific (87%) but lacked sensitivity (35%). The positive predictive value for HIV seropositivity was 25%. This study suggests that it is more difficult to define AIDS clinically in children than in adults and that the utility of the proposed WHO clinical case definition for pediatric AIDS for surveillance of children's AIDS in Africa is limited

KW - B780-tropical-medicine

KW - Viral diseases

KW - AIDS

KW - Diagnosis

KW - Immunology

KW - Africa

KW - Antibodies

KW - Children

KW - Diagnostic errors

KW - Evaluation studies

KW - Human

KW - HIV

KW - Infants

KW - Case definition

KW - Kinshasa

KW - Congo-Kinshasa

KW - Africa-Central

M3 - A2: International peer reviewed article (not A1-type)

SN - 0269-9370

VL - 1

SP - 151

EP - 153

JO - AIDS

JF - AIDS

ER -

Evaluation of a clinical case definition of AIDS in African children

Abstract

Keywords

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