Evaluation of a clinical case definition of AIDS in African children

RL Colebunders, A Greenberg, P Nguyen-Dinh, H Francis, N Kabote, I Lebughe, F Davachi, TC Quinn, P Piot

    Research output: Contribution to journalA2: International peer reviewed article (not A1-type)

    Abstract

    In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa, Zaire. Twenty-one (13%) of these children were seropositive for HIV. In this population, the clinical case definition of pediatric AIDS was found to be fairly specific (87%) but lacked sensitivity (35%). The positive predictive value for HIV seropositivity was 25%. This study suggests that it is more difficult to define AIDS clinically in children than in adults and that the utility of the proposed WHO clinical case definition for pediatric AIDS for surveillance of children's AIDS in Africa is limited
    Original languageEnglish
    JournalAIDS
    Volume1
    Pages (from-to)151-153
    ISSN0269-9370
    Publication statusPublished - 1987

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • AIDS
    • Diagnosis
    • Immunology
    • Africa
    • Antibodies
    • Children
    • Diagnostic errors
    • Evaluation studies
    • Human
    • HIV
    • Infants
    • Case definition
    • Kinshasa
    • Congo-Kinshasa
    • Africa-Central

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