Evaluation of biological activities of triterpenoid saponins from Maesa lanceolata

JB Sindambiwe, M Calomme, S Geerts, L Pieters, AJ Vlietinck, DA Vanden Berghe

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    From a bioassay-guided fractionation procedure using Herpes simplex virus type 1 as the target model, a virucidal saponin mixture (maesasaponin mixture B) was isolated from the MeOH extract of leaves of Maesa lanceolata. The maesasaponin mixture B consisted of six homologous oleanane-type triterpenoid saponins 1-6, identified by 1H, 13C, and 2D NMR spectroscopy and mass spectrometry. The maesasaponin mixture B (1-6) showed several biological activities expected for saponins. It exhibited a moderate virucidal activity against enveloped viruses. The maesasaponin mixture B (1-6) was tested for further properties. The saponin mixture was found to be highly hemolytic and molluscicidal: it hemolyzed 50% of human erythrocytes (1% suspension) at a concentration estimated at 1.6 microg/mL and exerted against Biomphalaria glabrata snails a severe toxic effect with LD95 and LD50 values of 4.1 and 2.3 ppm, respectively. In addition, the maesasaponin mixture B (1-6) showed moderate fungistatic and antimutagenic properties. The evaluation of these diverse activities is described
    Original languageEnglish
    JournalJournal of Natural Products
    Volume61
    Pages (from-to)585-590
    Publication statusPublished - 1998

    Keywords

    • B780-tropical-medicine
    • Medicinal plants
    • Pharmacology
    • Saponins

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