Evaluation of the effectiveness of chemical control for Chagas disease vectors in Loja Province, Ecuador

Mario J. Grijalva, Anita G. Villacis, Sofia Ocana-Mayorga, Cesar A. Yumiseva, Claudia Nieto-Sanchez, Esteban G. Baus, Ana L. Moncayo

Research output: Contribution to journalA1: Web of Science-articlepeer-review

Abstract

The objective of this study was to evaluate the effectiveness of selective and community-wide house insecticide spraying in controlling triatomines in the subtropical areas of Loja Province, Ecuador. We designed a quasi-experimental pre-post-test without a control group to compare entomological levels before and after spraying. The baseline study was conducted in 2008. Second, third, and fourth visits were conducted in 2010, 2011, and 2012 in three rural communities. Out of the 130 domestic units (DU) visited, 41 domestic units were examined in each of the four visits. Selective and community-wide insecticide interventions included spraying with 5% deltamethrin at 25 mg/m(2) active ingredient. At each visit, a questionnaire was administered to identify the characteristics of households, and DUs were searched for triatomine bugs. In addition, parasitological analysis was carried out in life triatomines. One and two rounds of selective insecticide spraying decreased the probability of infestation by 62% (pairwise odds ratios [POR] 0.38, 95% confidence interval [CI] 0.17-0.89, p = 0.024) and 51% (POR 0.49, 95% CI 0.23-1.01, p = 0.054), respectively. A similar effect was observed after one round of community-wide insecticide application in Chaquizhca and Guara (POR 0.55, CI 0.24-1.25, p = 0.155) and Bellamaria (POR 0.62, CI 0.22-1.79, p = 0.379); however, it was not statistically significant. Trypanosoma cruzi infection in triatomines (n = 483) increased overtime, from 2008 (42.9% and 8.5% for Rhodnius ecuadoriensis and Panstrongylus chinai, respectively) to 2012 (79.5% and 100%). Neither of the two spraying methodologies was effective for triatomine control in this area and our results point to a high likelihood of reinfestation after insecticide application. This underscores the importance of the implementation of physical barriers that prevent invasion and colonization of triatomines in households, such as home improvement initiatives, accompanied by a concerted effort to address the underlying socioeconomic issues that keep this population at risk of developing Chagas disease.

Original languageEnglish
JournalVector-Borne and Zoonotic Diseases
Volume22
Issue number9
Pages (from-to)449-458
Number of pages10
ISSN1530-3667
DOIs
Publication statusPublished - 2022

Keywords

  • Chagas disease
  • Trypanosoma cruzi
  • triatomine
  • control
  • insecticide
  • Ecuador
  • HEMIPTERA REDUVIIDAE TRIATOMINAE
  • TRYPANOSOMA-CRUZI
  • INSECTICIDE RESISTANCE
  • INFESTANS HEMIPTERA
  • DEFECATION PATTERNS
  • LIFE-CYCLE
  • POPULATIONS
  • DELTAMETHRIN
  • RANGELI
  • REGIONS
  • Triatoma
  • Chagas Disease/epidemiology
  • Ecuador/epidemiology
  • Animals
  • Insecticides/pharmacology
  • Disease Vectors

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