Evaluation of the WHO clinical case definition for AIDS in rural Zaire

KM De Cock; R Colebunders; H Francis; N Nzilambi; M Laga; RW Ryder; M Bondjobo; JB McCormick; P Piot

Evaluation of the WHO clinical case definition for AIDS in rural Zaire

KM De Cock, R Colebunders, H Francis, N Nzilambi, M Laga, RW Ryder, M Bondjobo, JB McCormick, P Piot

Sexual Health including HIV

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

The clinical case definition for AIDS proposed by WHO for use in Africa was evaluated against HIV antibody status in 72 patients in rural Zaire. Twenty-one (29%) of the patients were antibody-positive. For diagnosing anti-HIV seropositivity, the case definition had a sensitivity of 52%, a specificity of 78%, a positive predictive value of 50% and a negative predictive value of 80%. Calculation of the positive predictive value at different levels of prevalence of HIV infection suggests that the case definition operates at maximum reliability in selected high-risk groups. Modifications to the case definition should be evaluated to try and improve its sensitivity and positive predictive value

Original language	English
Journal	AIDS
Volume	2
Pages (from-to)	219-221
ISSN	0269-9370
Publication status	Published - 1988

Keywords

B780-tropical-medicine
Viral diseases
AIDS
Diagnosis
HIV
Seropositivity
Epidemiology
Rural
Case definition
Congo-Kinshasa
Africa-Central

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title = "Evaluation of the WHO clinical case definition for AIDS in rural Zaire",

abstract = "The clinical case definition for AIDS proposed by WHO for use in Africa was evaluated against HIV antibody status in 72 patients in rural Zaire. Twenty-one (29%) of the patients were antibody-positive. For diagnosing anti-HIV seropositivity, the case definition had a sensitivity of 52%, a specificity of 78%, a positive predictive value of 50% and a negative predictive value of 80%. Calculation of the positive predictive value at different levels of prevalence of HIV infection suggests that the case definition operates at maximum reliability in selected high-risk groups. Modifications to the case definition should be evaluated to try and improve its sensitivity and positive predictive value",

keywords = "B780-tropical-medicine, Viral diseases, AIDS, Diagnosis, HIV, Seropositivity, Epidemiology, Rural, Case definition, Congo-Kinshasa, Africa-Central",

author = "{De Cock}, KM and R Colebunders and H Francis and N Nzilambi and M Laga and RW Ryder and M Bondjobo and JB McCormick and P Piot",

year = "1988",

language = "English",

volume = "2",

pages = "219--221",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams & Wilkins",

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TY - JOUR

T1 - Evaluation of the WHO clinical case definition for AIDS in rural Zaire

AU - De Cock, KM

AU - Colebunders, R

AU - Francis, H

AU - Nzilambi, N

AU - Laga, M

AU - Ryder, RW

AU - Bondjobo, M

AU - McCormick, JB

AU - Piot, P

PY - 1988

Y1 - 1988

N2 - The clinical case definition for AIDS proposed by WHO for use in Africa was evaluated against HIV antibody status in 72 patients in rural Zaire. Twenty-one (29%) of the patients were antibody-positive. For diagnosing anti-HIV seropositivity, the case definition had a sensitivity of 52%, a specificity of 78%, a positive predictive value of 50% and a negative predictive value of 80%. Calculation of the positive predictive value at different levels of prevalence of HIV infection suggests that the case definition operates at maximum reliability in selected high-risk groups. Modifications to the case definition should be evaluated to try and improve its sensitivity and positive predictive value

AB - The clinical case definition for AIDS proposed by WHO for use in Africa was evaluated against HIV antibody status in 72 patients in rural Zaire. Twenty-one (29%) of the patients were antibody-positive. For diagnosing anti-HIV seropositivity, the case definition had a sensitivity of 52%, a specificity of 78%, a positive predictive value of 50% and a negative predictive value of 80%. Calculation of the positive predictive value at different levels of prevalence of HIV infection suggests that the case definition operates at maximum reliability in selected high-risk groups. Modifications to the case definition should be evaluated to try and improve its sensitivity and positive predictive value

KW - B780-tropical-medicine

KW - Viral diseases

KW - AIDS

KW - Diagnosis

KW - HIV

KW - Seropositivity

KW - Epidemiology

KW - Rural

KW - Case definition

KW - Congo-Kinshasa

KW - Africa-Central

M3 - A1: Web of Science-article

SN - 0269-9370

VL - 2

SP - 219

EP - 221

JO - AIDS

JF - AIDS

ER -

Evaluation of the WHO clinical case definition for AIDS in rural Zaire

Abstract

Keywords

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