Evaluation of the WHO clinical case definition for AIDS in rural Zaire

KM De Cock, R Colebunders, H Francis, N Nzilambi, M Laga, RW Ryder, M Bondjobo, JB McCormick, P Piot

Research output: Contribution to journalA1: Web of Science-articlepeer-review


The clinical case definition for AIDS proposed by WHO for use in Africa was evaluated against HIV antibody status in 72 patients in rural Zaire. Twenty-one (29%) of the patients were antibody-positive. For diagnosing anti-HIV seropositivity, the case definition had a sensitivity of 52%, a specificity of 78%, a positive predictive value of 50% and a negative predictive value of 80%. Calculation of the positive predictive value at different levels of prevalence of HIV infection suggests that the case definition operates at maximum reliability in selected high-risk groups. Modifications to the case definition should be evaluated to try and improve its sensitivity and positive predictive value
Original languageEnglish
Pages (from-to)219-221
Publication statusPublished - 1988


  • B780-tropical-medicine
  • Viral diseases
  • AIDS
  • Diagnosis
  • HIV
  • Seropositivity
  • Epidemiology
  • Rural
  • Case definition
  • Congo-Kinshasa
  • Africa-Central


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