Extensively Drug-Resistant Tuberculosis with Conflicting Resistance Testing Results, Lesotho

Kwonjune J. Seung; Meseret Asfaw; Mikanda Kunda; Llang Bridget Maama-Maime; Joalane Makaka; Mabatloung Mofolo; Stephane Mpinda; Melino Ndayizigiye; Shaheed Vally Omar; Prithiv Prasad; Praharshinie Rupasinghe; Chase Yarbrough; Lawrence Oyewusi

doi:10.3201/eid3111.250885

Extensively Drug-Resistant Tuberculosis with Conflicting Resistance Testing Results, Lesotho

Kwonjune J. Seung
, Meseret Asfaw
, Mikanda Kunda
, Llang Bridget Maama-Maime
, Joalane Makaka
, Mabatloung Mofolo
, Stephane Mpinda
, Melino Ndayizigiye
, Shaheed Vally Omar
, Prithiv Prasad
, Praharshinie Rupasinghe
, Chase Yarbrough
, Lawrence Oyewusi

Mycobacteriology

Research output: Contribution to journal › Letter › peer-review

Abstract

A patient with extensively drug-resistant tuberculosis in Lesotho recovered successfully after failed treatment with bedaquiline, delamanid, linezolid, and clofazimine. Whole-genome sequencing and broth microdilution testing results were not in agreement, illustrating the urgent need for studies that correlate phenotypic and genotypic resistance testing with clinical response.

Original language	English
Journal	Emerging Infectious Diseases
Volume	31
Issue number	11
Pages (from-to)	2185-2187
Number of pages	3
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid3111.250885
Publication status	Published - Nov-2025

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abstract = "A patient with extensively drug-resistant tuberculosis in Lesotho recovered successfully after failed treatment with bedaquiline, delamanid, linezolid, and clofazimine. Whole-genome sequencing and broth microdilution testing results were not in agreement, illustrating the urgent need for studies that correlate phenotypic and genotypic resistance testing with clinical response.",

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AU - Seung, Kwonjune J.

AU - Asfaw, Meseret

AU - Kunda, Mikanda

AU - Maama-Maime, Llang Bridget

AU - Makaka, Joalane

AU - Mofolo, Mabatloung

AU - Mpinda, Stephane

AU - Ndayizigiye, Melino

AU - Omar, Shaheed Vally

AU - Prasad, Prithiv

AU - Rupasinghe, Praharshinie

AU - Yarbrough, Chase

AU - Oyewusi, Lawrence

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AB - A patient with extensively drug-resistant tuberculosis in Lesotho recovered successfully after failed treatment with bedaquiline, delamanid, linezolid, and clofazimine. Whole-genome sequencing and broth microdilution testing results were not in agreement, illustrating the urgent need for studies that correlate phenotypic and genotypic resistance testing with clinical response.

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Extensively Drug-Resistant Tuberculosis with Conflicting Resistance Testing Results, Lesotho

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