False rifampicin resistance in Xpert Ultra applied to lymph node aspirate: a case report

Kamela C S Ng; Leen Rigouts; Bouke C de Jong; Lutgarde Lynen

doi:10.1093/ofid/ofaa204

False rifampicin resistance in Xpert Ultra applied to lymph node aspirate: a case report

Kamela C S Ng, Leen Rigouts, Bouke C de Jong, Lutgarde Lynen

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Abstract

A 36-year-old male patient was diagnosed with tuberculosis in Antwerp, Belgium, in May 2018. His lymph node aspirate initially tested rifampicin resistant in Xpert MTB/RIF Ultra, but tested susceptible in all other tests including targeted deep sequencing due to a rare matrix effect in the Xpert MTB/RIF Ultra reaction tube.

Original language	English
Article number	ofaa204
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	6
Number of pages	3
ISSN	2328-8957
DOIs	https://doi.org/10.1093/ofid/ofaa204
Publication status	Published - 2020

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10.1093/ofid/ofaa204Licence: CC BY-NC-ND

2020ofidofaa204Final published version, 347 KBLicence: CC BY-NC-ND

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title = "False rifampicin resistance in Xpert Ultra applied to lymph node aspirate: a case report",

abstract = "A 36-year-old male patient was diagnosed with tuberculosis in Antwerp, Belgium, in May 2018. His lymph node aspirate initially tested rifampicin resistant in Xpert MTB/RIF Ultra, but tested susceptible in all other tests including targeted deep sequencing due to a rare matrix effect in the Xpert MTB/RIF Ultra reaction tube.",

author = "Ng, {Kamela C S} and Leen Rigouts and {de Jong}, {Bouke C} and Lutgarde Lynen",

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AU - Ng, Kamela C S

AU - Rigouts, Leen

AU - de Jong, Bouke C

AU - Lynen, Lutgarde

N1 - FTX; DOAJ; OACHECK; (CC BY-NC-ND 4.0); © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2020

Y1 - 2020

N2 - A 36-year-old male patient was diagnosed with tuberculosis in Antwerp, Belgium, in May 2018. His lymph node aspirate initially tested rifampicin resistant in Xpert MTB/RIF Ultra, but tested susceptible in all other tests including targeted deep sequencing due to a rare matrix effect in the Xpert MTB/RIF Ultra reaction tube.

AB - A 36-year-old male patient was diagnosed with tuberculosis in Antwerp, Belgium, in May 2018. His lymph node aspirate initially tested rifampicin resistant in Xpert MTB/RIF Ultra, but tested susceptible in all other tests including targeted deep sequencing due to a rare matrix effect in the Xpert MTB/RIF Ultra reaction tube.

U2 - 10.1093/ofid/ofaa204

DO - 10.1093/ofid/ofaa204

M3 - A1: Web of Science-article

C2 - 32607388

SN - 2328-8957

VL - 7

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 6

M1 - ofaa204

ER -

False rifampicin resistance in Xpert Ultra applied to lymph node aspirate: a case report

Abstract

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