Abstract
The status of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia. Among 240 mosquito samples from 15 villages of southwestern Ethiopia that were screened by allele-specific polymerase chain reaction for kdr mutations, the West African kdr mutation (L1014F) was detected in almost all specimens (98.5%), whereas the East African kdr mutation (L1014S) was absent. Moreover, the mortality of An. gambiae s.l. to diagnostic dosages of 4% DDT, 0.75% permethrin, and 0.05% deltamethrin from bioassay results was 1.0%, 18.1%, and 82.2%, respectively. We report here the highest kdr allele frequency ever observed in An. arabiensis and its implications in malaria vector control in Ethiopia are discussed
Original language | English |
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Journal | American Journal of Tropical Medicine and Hygiene |
Volume | 83 |
Issue number | 1 |
Pages (from-to) | 122-125 |
Number of pages | 4 |
ISSN | 0002-9637 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- B780-tropical-medicine
- Protozoal diseases
- Malaria
- Plasmodium falciparum
- Vectors
- Mosquitoes
- Anopheles arabiensis
- Screening
- kdr
- Alleles
- Frequency
- Polymerase chain reaction
- PCR
- Mutations
- DNA extraction
- Mortality rates
- Knockdown resistance
- Ethiopia
- Africa-East