First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from Ethiopia

D Yewhalaw, W Van Bortel, L Denis, M Coosemans, L Duchateau, N Speybroeck

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    The status of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia. Among 240 mosquito samples from 15 villages of southwestern Ethiopia that were screened by allele-specific polymerase chain reaction for kdr mutations, the West African kdr mutation (L1014F) was detected in almost all specimens (98.5%), whereas the East African kdr mutation (L1014S) was absent. Moreover, the mortality of An. gambiae s.l. to diagnostic dosages of 4% DDT, 0.75% permethrin, and 0.05% deltamethrin from bioassay results was 1.0%, 18.1%, and 82.2%, respectively. We report here the highest kdr allele frequency ever observed in An. arabiensis and its implications in malaria vector control in Ethiopia are discussed
    Original languageEnglish
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume83
    Issue number1
    Pages (from-to)122-125
    Number of pages4
    ISSN0002-9637
    DOIs
    Publication statusPublished - 2010

    Keywords

    • B780-tropical-medicine
    • Protozoal diseases
    • Malaria
    • Plasmodium falciparum
    • Vectors
    • Mosquitoes
    • Anopheles arabiensis
    • Screening
    • kdr
    • Alleles
    • Frequency
    • Polymerase chain reaction
    • PCR
    • Mutations
    • DNA extraction
    • Mortality rates
    • Knockdown resistance
    • Ethiopia
    • Africa-East

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