First newborn baby to receive experimental therapies survives Ebola virus disease

Jenny Dornemann, Chiara Burzio, Axelle Ronsse, Armand Sprecher, Hilde De Clerck, Michel Van Herp, Marie-Claire Kolie, Vesselina Yosifiva, Severine Caluwaerts, Anita K. McElroy, Annick Antierens

Research output: Contribution to journalA1: Web of Science-article

Abstract

A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.

Original languageEnglish
JournalJournal of Infectious Diseases
Volume215
Issue number2
Pages (from-to)171-174
Number of pages4
ISSN0022-1899
DOIs
Publication statusPublished - 2017

Keywords

  • Ebola
  • ZMapp
  • GS-5734
  • IMMUNITY

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