First newborn baby to receive experimental therapies survives Ebola virus disease

Jenny Dornemann; Chiara Burzio; Axelle Ronsse; Armand Sprecher; Hilde De Clerck; Michel Van Herp; Marie-Claire Kolie; Vesselina Yosifiva; Severine Caluwaerts; Anita K. McElroy; Annick Antierens

doi:10.1093/infdis/jiw493

First newborn baby to receive experimental therapies survives Ebola virus disease

Jenny Dornemann, Chiara Burzio, Axelle Ronsse, Armand Sprecher, Hilde De Clerck, Michel Van Herp, Marie-Claire Kolie, Vesselina Yosifiva, Severine Caluwaerts, Anita K. McElroy, Annick Antierens

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.

Original language	English
Journal	Journal of Infectious Diseases
Volume	215
Issue number	2
Pages (from-to)	171-174
Number of pages	4
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiw493
Publication status	Published - 2017

Keywords

Ebola
ZMapp
GS-5734
IMMUNITY

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10.1093/infdis/jiw493

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title = "First newborn baby to receive experimental therapies survives Ebola virus disease",

abstract = "A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.",

keywords = "Ebola, ZMapp, GS-5734, IMMUNITY",

author = "Jenny Dornemann and Chiara Burzio and Axelle Ronsse and Armand Sprecher and {De Clerck}, Hilde and {Van Herp}, Michel and Marie-Claire Kolie and Vesselina Yosifiva and Severine Caluwaerts and McElroy, {Anita K.} and Annick Antierens",

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doi = "10.1093/infdis/jiw493",

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journal = "Journal of Infectious Diseases",

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TY - JOUR

T1 - First newborn baby to receive experimental therapies survives Ebola virus disease

AU - Dornemann, Jenny

AU - Burzio, Chiara

AU - Ronsse, Axelle

AU - Sprecher, Armand

AU - De Clerck, Hilde

AU - Van Herp, Michel

AU - Kolie, Marie-Claire

AU - Yosifiva, Vesselina

AU - Caluwaerts, Severine

AU - McElroy, Anita K.

AU - Antierens, Annick

N1 - PPU

PY - 2017

Y1 - 2017

N2 - A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.

AB - A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.

KW - Ebola

KW - ZMapp

KW - GS-5734

KW - IMMUNITY

U2 - 10.1093/infdis/jiw493

DO - 10.1093/infdis/jiw493

M3 - A1: Web of Science-article

SN - 0022-1899

VL - 215

SP - 171

EP - 174

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 2

ER -

First newborn baby to receive experimental therapies survives Ebola virus disease

Abstract

Keywords

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