Flavivirus antibodies reactive to Zika virus detected in multiple species of nonhuman primates in Kenya, 2008-2017

Albina Makio; Marc-Alain Widdowson; Peris Ambala; Hastings Ozwara; Peninah Munyua; Elizabeth Hunsperger

doi:10.1089/vbz.2022.0080

Flavivirus antibodies reactive to Zika virus detected in multiple species of nonhuman primates in Kenya, 2008-2017

Albina Makio, Marc-Alain Widdowson, Peris Ambala, Hastings Ozwara, Peninah Munyua, Elizabeth Hunsperger

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Background: Zika virus (ZIKV), first described in 1947, is an arthropod-borne virus associated with sporadic outbreaks and interepidemic transmission. Recent studies have implicated nonhuman primates (NHPs) as the probable reservoir hosts. We tested archived serum samples of NHPs collected in Kenya for evidence of neutralizing ZIKV antibodies.

Methods: We randomly selected 212 archived serum samples from Institute of Primate Research in Kenya collected between 1992 and 2017. These specimens were tested by microneutralization test.

Results: The 212 serum samples were collected in 7 counties from 87 (41.0%) Olive baboons, 69 (32.5%) Vervet monkeys, and 49 (23.1%) Sykes monkeys. Half (50.9%) were male and 56.4% were adult. We detected ZIKV antibodies in 38 (17.9%; 95% confidence interval: 13.3-23.6) samples.

Conclusions: These results suggest ZIKV transmission and potential maintenance in nature by NHPs in Kenya.

Original language	English
Journal	Vector-Borne and Zoonotic Diseases
Volume	23
Issue number	7
Pages (from-to)	393-396
Number of pages	4
ISSN	1530-3667
DOIs	https://doi.org/10.1089/vbz.2022.0080
Publication status	Published - 2023

Keywords

Animals
Antibodies, Neutralizing
Antibodies, Viral
Chlorocebus aethiops
Female
Kenya/epidemiology
Male
Primates
Zika Virus
Zika Virus Infection/epidemiology

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10.1089/vbz.2022.0080

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@article{36b53bba5b204228b699c0a1e615dc1b,

title = "Flavivirus antibodies reactive to Zika virus detected in multiple species of nonhuman primates in Kenya, 2008-2017",

abstract = "Background: Zika virus (ZIKV), first described in 1947, is an arthropod-borne virus associated with sporadic outbreaks and interepidemic transmission. Recent studies have implicated nonhuman primates (NHPs) as the probable reservoir hosts. We tested archived serum samples of NHPs collected in Kenya for evidence of neutralizing ZIKV antibodies. Methods: We randomly selected 212 archived serum samples from Institute of Primate Research in Kenya collected between 1992 and 2017. These specimens were tested by microneutralization test. Results: The 212 serum samples were collected in 7 counties from 87 (41.0%) Olive baboons, 69 (32.5%) Vervet monkeys, and 49 (23.1%) Sykes monkeys. Half (50.9%) were male and 56.4% were adult. We detected ZIKV antibodies in 38 (17.9%; 95% confidence interval: 13.3-23.6) samples. Conclusions: These results suggest ZIKV transmission and potential maintenance in nature by NHPs in Kenya.",

keywords = "Animals, Antibodies, Neutralizing, Antibodies, Viral, Chlorocebus aethiops, Female, Kenya/epidemiology, Male, Primates, Zika Virus, Zika Virus Infection/epidemiology",

author = "Albina Makio and Marc-Alain Widdowson and Peris Ambala and Hastings Ozwara and Peninah Munyua and Elizabeth Hunsperger",

note = "NPP; No ITM affiliation?",

year = "2023",

doi = "10.1089/vbz.2022.0080",

language = "English",

volume = "23",

pages = "393--396",

journal = "Vector-Borne and Zoonotic Diseases",

issn = "1530-3667",

publisher = "Mary Ann Liebert Inc.",

number = "7",

}

TY - JOUR

T1 - Flavivirus antibodies reactive to Zika virus detected in multiple species of nonhuman primates in Kenya, 2008-2017

AU - Makio, Albina

AU - Widdowson, Marc-Alain

AU - Ambala, Peris

AU - Ozwara, Hastings

AU - Munyua, Peninah

AU - Hunsperger, Elizabeth

N1 - NPP; No ITM affiliation?

PY - 2023

Y1 - 2023

N2 - Background: Zika virus (ZIKV), first described in 1947, is an arthropod-borne virus associated with sporadic outbreaks and interepidemic transmission. Recent studies have implicated nonhuman primates (NHPs) as the probable reservoir hosts. We tested archived serum samples of NHPs collected in Kenya for evidence of neutralizing ZIKV antibodies. Methods: We randomly selected 212 archived serum samples from Institute of Primate Research in Kenya collected between 1992 and 2017. These specimens were tested by microneutralization test. Results: The 212 serum samples were collected in 7 counties from 87 (41.0%) Olive baboons, 69 (32.5%) Vervet monkeys, and 49 (23.1%) Sykes monkeys. Half (50.9%) were male and 56.4% were adult. We detected ZIKV antibodies in 38 (17.9%; 95% confidence interval: 13.3-23.6) samples. Conclusions: These results suggest ZIKV transmission and potential maintenance in nature by NHPs in Kenya.

AB - Background: Zika virus (ZIKV), first described in 1947, is an arthropod-borne virus associated with sporadic outbreaks and interepidemic transmission. Recent studies have implicated nonhuman primates (NHPs) as the probable reservoir hosts. We tested archived serum samples of NHPs collected in Kenya for evidence of neutralizing ZIKV antibodies. Methods: We randomly selected 212 archived serum samples from Institute of Primate Research in Kenya collected between 1992 and 2017. These specimens were tested by microneutralization test. Results: The 212 serum samples were collected in 7 counties from 87 (41.0%) Olive baboons, 69 (32.5%) Vervet monkeys, and 49 (23.1%) Sykes monkeys. Half (50.9%) were male and 56.4% were adult. We detected ZIKV antibodies in 38 (17.9%; 95% confidence interval: 13.3-23.6) samples. Conclusions: These results suggest ZIKV transmission and potential maintenance in nature by NHPs in Kenya.

KW - Animals

KW - Antibodies, Neutralizing

KW - Antibodies, Viral

KW - Chlorocebus aethiops

KW - Female

KW - Kenya/epidemiology

KW - Male

KW - Primates

KW - Zika Virus

KW - Zika Virus Infection/epidemiology

U2 - 10.1089/vbz.2022.0080

DO - 10.1089/vbz.2022.0080

M3 - A1: Web of Science-article

C2 - 37205849

SN - 1530-3667

VL - 23

SP - 393

EP - 396

JO - Vector-Borne and Zoonotic Diseases

JF - Vector-Borne and Zoonotic Diseases

IS - 7

ER -

Flavivirus antibodies reactive to Zika virus detected in multiple species of nonhuman primates in Kenya, 2008-2017

Abstract

Keywords

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