From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study

K. Stoffels, C. Allix-Beguec, G. Groenen, M. Wanlin, D. Berkvens, V. Mathys, P. Supply, M. Fauville-Dufaux

    Research output: Contribution to journalA1: Web of Science-article

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    Abstract

    BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR-TB) represents an enormous challenge to Public Health globally. METHODS: Progression towards XDR-TB was investigated in Belgium, a country with a typically low TB incidence, by analyzing the magnitude, characteristics, and treatment success of multidrug-resistant tuberculosis (MDR-TB) through a population-based study from 1994 to 2008. RESULTS: Among the 174 MDR-TB patients, 81% were foreign-born, 48% of these being asylum seekers. Although the number of MDR-TB patients remained stable through the study period at around 15 new cases annually, frequencies of resistance of the patients' first MDR-TB isolate to second-line drugs increased, as well as the total number of antibiotics it was resistant to (p
    Original languageEnglish
    JournalPLoS ONE
    Volume8
    Issue number5
    Pages (from-to)e63128
    ISSN1932-6203
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Bacterial diseases
    • Tuberculosis
    • Mycobacterium tuberculosis
    • Epidemiology
    • Trends
    • Drug resistance
    • Risk groups
    • Immigrants
    • Asylum seekers
    • Antibiotics
    • Second-line drugs
    • Asia
    • Europe-Central
    • Europe-East
    • Beijing genotype
    • Strains
    • Belgium
    • Europe-West

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