From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study

K. Stoffels; C. Allix-Beguec; G. Groenen; M. Wanlin; D. Berkvens; V. Mathys; P. Supply; M. Fauville-Dufaux

doi:10.1371/journal.pone.0063128

From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study

K. Stoffels, C. Allix-Beguec, G. Groenen, M. Wanlin, D. Berkvens, V. Mathys, P. Supply, M. Fauville-Dufaux

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Abstract

BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR-TB) represents an enormous challenge to Public Health globally. METHODS: Progression towards XDR-TB was investigated in Belgium, a country with a typically low TB incidence, by analyzing the magnitude, characteristics, and treatment success of multidrug-resistant tuberculosis (MDR-TB) through a population-based study from 1994 to 2008. RESULTS: Among the 174 MDR-TB patients, 81% were foreign-born, 48% of these being asylum seekers. Although the number of MDR-TB patients remained stable through the study period at around 15 new cases annually, frequencies of resistance of the patients' first MDR-TB isolate to second-line drugs increased, as well as the total number of antibiotics it was resistant to (p

Original language	English
Journal	PLoS ONE
Volume	8
Issue number	5
Pages (from-to)	e63128
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0063128
Publication status	Published - 2013

Keywords

Bacterial diseases
Tuberculosis
Mycobacterium tuberculosis
Epidemiology
Trends
Drug resistance
Risk groups
Immigrants
Asylum seekers
Antibiotics
Second-line drugs
Asia
Europe-Central
Europe-East
Beijing genotype
Strains
Belgium
Europe-West

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Cite this

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title = "From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study",

abstract = "BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR-TB) represents an enormous challenge to Public Health globally. METHODS: Progression towards XDR-TB was investigated in Belgium, a country with a typically low TB incidence, by analyzing the magnitude, characteristics, and treatment success of multidrug-resistant tuberculosis (MDR-TB) through a population-based study from 1994 to 2008. RESULTS: Among the 174 MDR-TB patients, 81% were foreign-born, 48% of these being asylum seekers. Although the number of MDR-TB patients remained stable through the study period at around 15 new cases annually, frequencies of resistance of the patients' first MDR-TB isolate to second-line drugs increased, as well as the total number of antibiotics it was resistant to (p",

keywords = "Bacterial diseases, Tuberculosis, Mycobacterium tuberculosis, Epidemiology, Trends, Drug resistance, Risk groups, Immigrants, Asylum seekers, Antibiotics, Second-line drugs, Asia, Europe-Central, Europe-East, Beijing genotype, Strains, Belgium, Europe-West",

author = "K. Stoffels and C. Allix-Beguec and G. Groenen and M. Wanlin and D. Berkvens and V. Mathys and P. Supply and M. Fauville-Dufaux",

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doi = "10.1371/journal.pone.0063128",

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T1 - From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study

AU - Stoffels, K.

AU - Allix-Beguec, C.

AU - Groenen, G.

AU - Wanlin, M.

AU - Berkvens, D.

AU - Mathys, V.

AU - Supply, P.

AU - Fauville-Dufaux, M.

N1 - ITG-B5A; DBM; U-VEPID; JIF; DOI; PDF; E-only; Abstract; DSPACE56

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR-TB) represents an enormous challenge to Public Health globally. METHODS: Progression towards XDR-TB was investigated in Belgium, a country with a typically low TB incidence, by analyzing the magnitude, characteristics, and treatment success of multidrug-resistant tuberculosis (MDR-TB) through a population-based study from 1994 to 2008. RESULTS: Among the 174 MDR-TB patients, 81% were foreign-born, 48% of these being asylum seekers. Although the number of MDR-TB patients remained stable through the study period at around 15 new cases annually, frequencies of resistance of the patients' first MDR-TB isolate to second-line drugs increased, as well as the total number of antibiotics it was resistant to (p

AB - BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR-TB) represents an enormous challenge to Public Health globally. METHODS: Progression towards XDR-TB was investigated in Belgium, a country with a typically low TB incidence, by analyzing the magnitude, characteristics, and treatment success of multidrug-resistant tuberculosis (MDR-TB) through a population-based study from 1994 to 2008. RESULTS: Among the 174 MDR-TB patients, 81% were foreign-born, 48% of these being asylum seekers. Although the number of MDR-TB patients remained stable through the study period at around 15 new cases annually, frequencies of resistance of the patients' first MDR-TB isolate to second-line drugs increased, as well as the total number of antibiotics it was resistant to (p

KW - Bacterial diseases

KW - Tuberculosis

KW - Mycobacterium tuberculosis

KW - Epidemiology

KW - Trends

KW - Drug resistance

KW - Risk groups

KW - Immigrants

KW - Asylum seekers

KW - Antibiotics

KW - Second-line drugs

KW - Asia

KW - Europe-Central

KW - Europe-East

KW - Beijing genotype

KW - Strains

KW - Belgium

KW - Europe-West

U2 - 10.1371/journal.pone.0063128

DO - 10.1371/journal.pone.0063128

M3 - A1: Web of Science-article

C2 - 23671662

SN - 1932-6203

VL - 8

SP - e63128

JO - PLoS ONE

JF - PLoS ONE

IS - 5

ER -

From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study

Abstract

Keywords

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