Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection

G Vanham; K Edmonds; L Qing; D Hom; Z Toossi; B Jones; CL Daley; B Huebner; L Kestens; P Gigase; JJ Ellner

doi:10.1046/j.1365-2249.1996.907600.x

Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection

G Vanham, K Edmonds, L Qing, D Hom, Z Toossi, B Jones, CL Daley, B Huebner, L Kestens, P Gigase, JJ Ellner

Virology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV⁻ and HIV⁺ pulmonary tuberculosis (TB) patients. Compared with controls, HLA^-DR expression on both CD4 and CD8 T cells from the HIV⁻ TB patients was approximately doubled; HLA-DR on T cells from the HIV+ group was tripled. The monocytes from both groups of patients expressed abnormally high levels of the Fcγ receptors I and III. Serum levels of tumour necrosis factor-alpha (TNF-α), neopterin and β2-microglobulin were increased in HIV⁻ and even more so in HIV⁺ TB patients. The expression of HLA-DR on T cell subsets and of FcγR on monocytes correlated with each other, but not with serum activation markers. This pattern of non-specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.

Original language	English
Journal	Clinical and Experimental Immunology
Volume	103
Issue number	1
Pages (from-to)	30-34
Number of pages	5
ISSN	0009-9104
DOIs	https://doi.org/10.1046/j.1365-2249.1996.907600.x
Publication status	Published - 1996

Keywords

B780-tropical-medicine
Immunology
Virology
HIV
Bacterial diseases
Tuberculosis

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10.1046/j.1365-2249.1996.907600.x

http://lib.itg.be/pdf/itg/1996/1996ceim0030.pdf

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title = "Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection",

abstract = "Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV− and HIV+ pulmonary tuberculosis (TB) patients. Compared with controls, HLA-DR expression on both CD4 and CD8 T cells from the HIV− TB patients was approximately doubled; HLA-DR on T cells from the HIV+ group was tripled. The monocytes from both groups of patients expressed abnormally high levels of the Fcγ receptors I and III. Serum levels of tumour necrosis factor-alpha (TNF-α), neopterin and β2-microglobulin were increased in HIV− and even more so in HIV+ TB patients. The expression of HLA-DR on T cell subsets and of FcγR on monocytes correlated with each other, but not with serum activation markers. This pattern of non-specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.",

keywords = "B780-tropical-medicine, Immunology, Virology, HIV, Bacterial diseases, Tuberculosis",

author = "G Vanham and K Edmonds and L Qing and D Hom and Z Toossi and B Jones and CL Daley and B Huebner and L Kestens and P Gigase and JJ Ellner",

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doi = "10.1046/j.1365-2249.1996.907600.x",

language = "English",

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TY - JOUR

T1 - Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection

AU - Vanham, G

AU - Edmonds, K

AU - Qing, L

AU - Hom, D

AU - Toossi, Z

AU - Jones, B

AU - Daley, CL

AU - Huebner, B

AU - Kestens, L

AU - Gigase, P

AU - Ellner, JJ

N1 - FTX: Abonnement

PY - 1996

Y1 - 1996

N2 - Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV− and HIV+ pulmonary tuberculosis (TB) patients. Compared with controls, HLA-DR expression on both CD4 and CD8 T cells from the HIV− TB patients was approximately doubled; HLA-DR on T cells from the HIV+ group was tripled. The monocytes from both groups of patients expressed abnormally high levels of the Fcγ receptors I and III. Serum levels of tumour necrosis factor-alpha (TNF-α), neopterin and β2-microglobulin were increased in HIV− and even more so in HIV+ TB patients. The expression of HLA-DR on T cell subsets and of FcγR on monocytes correlated with each other, but not with serum activation markers. This pattern of non-specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.

AB - Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV− and HIV+ pulmonary tuberculosis (TB) patients. Compared with controls, HLA-DR expression on both CD4 and CD8 T cells from the HIV− TB patients was approximately doubled; HLA-DR on T cells from the HIV+ group was tripled. The monocytes from both groups of patients expressed abnormally high levels of the Fcγ receptors I and III. Serum levels of tumour necrosis factor-alpha (TNF-α), neopterin and β2-microglobulin were increased in HIV− and even more so in HIV+ TB patients. The expression of HLA-DR on T cell subsets and of FcγR on monocytes correlated with each other, but not with serum activation markers. This pattern of non-specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.

KW - B780-tropical-medicine

KW - Immunology

KW - Virology

KW - HIV

KW - Bacterial diseases

KW - Tuberculosis

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:A1996TQ70700007

U2 - 10.1046/j.1365-2249.1996.907600.x

DO - 10.1046/j.1365-2249.1996.907600.x

M3 - A1: Web of Science-article

SN - 0009-9104

VL - 103

SP - 30

EP - 34

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 1

ER -

Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection

Abstract

Keywords

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